Adenosylhomocysteinase (AHCY)

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SAHH; AdoHcyase; S-Adenosylhomocysteine Hydrolase; S-adenosyl-L-homocysteine hydrolase

Adenosylhomocysteinase (AHCY)
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia.
In eukaryotes, this is the major route for disposal of the S-adenosylhomocysteine formed as a common product of each of many S-adenosylmethionine-dependent methyltransferases. The reaction is reversible, but under normal conditions the removal of both adenosine and homocysteine is sufficiently rapid to maintain the flux in the direction of hydrolysis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG465Hu01 Recombinant Adenosylhomocysteinase (AHCY) Positive Control; Immunogen; SDS-PAGE; WB.
APG465Hu01 Active Adenosylhomocysteinase (AHCY) Cell culture; Activity Assays.
Antibodies PAG465Hu01 Polyclonal Antibody to Adenosylhomocysteinase (AHCY) WB; IHC; ICC; IP.
MAG465Hu21 Monoclonal Antibody to Adenosylhomocysteinase (AHCY) WB; IHC; ICC; IP.
Assay Kits SEG465Hu ELISA Kit for Adenosylhomocysteinase (AHCY) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenosylhomocysteinase (AHCY) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenosylhomocysteinase (AHCY) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenosylhomocysteinase (AHCY) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenosylhomocysteinase (AHCY) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenosylhomocysteinase (AHCY) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenosylhomocysteinase (AHCY) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenosylhomocysteinase (AHCY) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenosylhomocysteinase (AHCY) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenosylhomocysteinase (AHCY) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenosylhomocysteinase (AHCY) ELISA Kit Customized Service Offer
  1. "Sequence of full length cDNA for human S-adenosylhomocysteine hydrolase."Ann. Hum. Genet. 53:169-175(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Limited proteolysis of S-adenosylhomocysteine hydrolase: implications for the three-dimensional structure."Arch. Biochem. Biophys. 319:365-371(1995) [PubMed] [Europe PMC] [Abstract]