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Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK (ZAK)

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MLT; MRK; MLK7; MLTK; HCCS4; Mitogen-activated protein kinase kinase kinase MLT; Human cervical cancer suppressor 4; Leucine zipper-and sterile alpha motif-containing kinase

Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK (ZAK)
CCC G345
MGI 2443258
PubMed 24170769
UniProt Q9NYL2
Wiki ZAK
ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm.
The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK (ZAK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK (ZAK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK (ZAK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK (ZAK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK (ZAK) ELISA Kit Customized Service Offer
  1. "Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif."Biochem. Biophys. Res. Commun. 274:811-816(2000) [PubMed] [Europe PMC] [Abstract].
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  4. "A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle."Biochem. Biophys. Res. Commun. 301:71-77(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN."J. Biochem. 133:181-187(2003) [PubMed] [Europe PMC] [Abstract]
  6. "A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development."Cancer Res. 64:3855-3864(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway."J. Biol. Chem. 279:47652-47660(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha."J. Biol. Chem. 280:13545-13553(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]