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Enterokinase (ENTK)

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PRSS7; TMPRSS15; Protease, Serine 7; Proenterokinase; Enteropeptidase; Transmembrane protease serine 15

Enterokinase (ENTK)
CCC G322
HGNC 9490
MGI 1197523
RGD 1311046
UniProt P98073

Enteropeptidase is an enzyme involved in human digestion. It is produced by cells in the duodenum wall, and is secreted from duodenum's glands, the crypts of Lieberkühn, whenever ingested food enters the duodenum from the stomach. Enteropeptidase has the critical job of turning trypsinogen (a zymogen) to trypsin, indirectly activating a number of pancreatic digestive enzymes.

Enteropeptidase is a serine protease enzyme (EC 3.4.21.9) which converts inactive trypsinogen into active trypsin by cleavage at the C-terminal end of the sequence. It consists of a disulfide-linked 82–140 kDa heavy chain which anchors enterokinase in the intestinal brush border membrane and a 35–62 kDa light chain which is the catalytic subunit.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Enterokinase (ENTK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Enterokinase (ENTK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enterokinase (ENTK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Enterokinase (ENTK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enterokinase (ENTK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG322Mu01 Recombinant Enterokinase (ENTK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Enterokinase (ENTK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enterokinase (ENTK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Enterokinase (ENTK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enterokinase (ENTK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG322Ra01 Recombinant Enterokinase (ENTK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG322Ra01 Polyclonal Antibody to Enterokinase (ENTK) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Enterokinase (ENTK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enterokinase (ENTK) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG322Bo01 Recombinant Enterokinase (ENTK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Enterokinase (ENTK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enterokinase (ENTK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Enterokinase (ENTK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enterokinase (ENTK) ELISA Kit Customized Service Offer
  1. "cDNA sequence and chromosomal localization of human enterokinase, the proteolytic activator of trypsinogen."Biochemistry 34:4562-4568(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency."Am. J. Hum. Genet. 70:20-25(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains."Proc. Natl. Acad. Sci. U.S.A. 91:7588-7592(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Crystal structure of a supercharged variant of the human enteropeptidase light chain."Proteins 80:1907-1910(2012) [PubMed] [Europe PMC] [Abstract]