Threonyl tRNA Synthetase 2, Mitochondrial (TARS2)

By searching databases for aminoacyl-tRNA synthetases containing a mitochondrial targeting sequence, Bonnefond et al. (2005) identified TARS2, which the called mitochondrial THRRS. The deduced 718-amino acid protein has an N-terminal mitochondrial targeting signal with a predicted cleavage site after residue 39.

TARS2 has characteristics of a class II mitochondrial aminoacyl-tRNA synthetase and is expected to function as a dimer. Bonnefond et al. (2005) determined that the TARS2 gene contains 18 exons and spans 19.6 kb. By genomic sequence analysis, Bonnefond et al. (2005) mapped the TARS2 gene to chromosome 1.