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Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2)

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AsnRS; Asparaginyl-tRNA synthetase

Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2)
CCC G132
HGNC 26274
MGI 2142075
RGD 1305145
UniProt Q96I59
By searching databases for aminoacyl-tRNA synthetases containing a mitochondrial targeting sequence, Bonnefond et al. (2005) identified NARS2, which the called mitochondrial ASNRS. The deduced 477-amino acid protein has an N-terminal mitochondrial targeting signal with a predicted cleavage site after residue 14. NARS2 has characteristics of a class II mitochondrial aminoacyl-tRNA synthetase and is expected to function as a dimer.
Bonnefond et al. (2005) determined that the NARS2 gene contains 14 exons and spans 137.8 kb.
By genomic sequence analysis, Bonnefond et al. (2005) mapped the NARS2 gene to chromosome 11.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG132Hu01 Recombinant Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG132Mu01 Recombinant Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG132Ra01 Recombinant Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2) ELISA Kit Customized Service Offer
  1. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS."Biochemistry 44:4805-4816(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Two siblings with homozygous pathogenic splice-site variant in mitochondrial asparaginyl-tRNA synthetase (NARS2)."Hum. Mutat. 36:222-231(2015) [PubMed] [Europe PMC] [Abstract]
  8. "Whole exome sequencing reveals mutations in NARS2 and PARS2, encoding the mitochondrial asparaginyl-tRNA synthetase and prolyl-tRNA synthetase, in patients with Alpers syndrome."Mol. Genet. Genomic Med. 3:59-68(2015) [PubMed] [Europe PMC] [Abstract]