≡

Anoctamin 6 (ANO6)

[Edit]

TMEM16F; SCAN channel; Transmembrane Protein 16F; Small-conductance calcium-activated nonselective cation channel

Anoctamin 6 (ANO6)
CCC F813
HGNC 25240
MGI 2145890
RGD 1304765
UniProt Q4KMQ2
By searching databases for sequences similar to TMEM16A, Katoh and Katoh (2004) identified TMEM16F. The deduced 892-amino acid protein contains 8 transmembrane domains. The N and C termini are cytoplasmic, and the extracellular regions contain 6 putative N-glycosylation sites. TMEM16F and TMEM16E share 50.3% amino acid identity. By EST database analysis, Katoh and Katoh (2004) determined that TMEM16F is expressed in embryonic stem cells, fetal liver, retina, chronic myelogenous leukemia, and intestinal cancer.Katoh and Katoh (2004) determined that the TMEM16F gene contains 20 exons and spans more than 119.7 kb.This locus is paralogous to the NELL1-TMEM16E locus on chromosome 11p15.1-p14.3. Katoh and Katoh (2004) also mapped the mouse Tmem16f gene to chromosome 15E3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF813Hu01 Recombinant Anoctamin 6 (ANO6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF813Hu01 Polyclonal Antibody to Anoctamin 6 (ANO6) WB
MAF813Hu21 Monoclonal Antibody to Anoctamin 6 (ANO6) WB; IHC; ICC; IP.
Assay Kits SEF813Hu ELISA Kit for Anoctamin 6 (ANO6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anoctamin 6 (ANO6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anoctamin 6 (ANO6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anoctamin 6 (ANO6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anoctamin 6 (ANO6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anoctamin 6 (ANO6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anoctamin 6 (ANO6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anoctamin 6 (ANO6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anoctamin 6 (ANO6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anoctamin 6 (ANO6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anoctamin 6 (ANO6) ELISA Kit Customized Service Offer
  1. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and characterization of TMEM16E and TMEM16F genes in silico."Int. J. Oncol. 24:1345-1349(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Expression and function of epithelial anoctamins."J. Biol. Chem. 285:7838-7845(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Calcium-dependent phospholipid scrambling by TMEM16F."Nature 468:834-838(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Anoctamins."Pflugers Arch. 462:195-208(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Anoctamin 6 is an essential component of the outwardly rectifying chloride channel."Proc. Natl. Acad. Sci. U.S.A. 108:18168-18172(2011) [PubMed] [Europe PMC] [Abstract]
  11. "ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins."Am. J. Physiol. 302:C482-C493(2012) [PubMed] [Europe PMC] [Abstract]
  12. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
  13. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Expression and function of epithelial anoctamins."Exp. Physiol. 97:184-192(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Anoctamins are a family of Ca2+ activated Cl- channels."J. Cell Sci. 125:4991-4998(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]