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Spondin 1 (SPON1)

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VSGP; F-spondin; F-spondin,Extracellular Matrix Protein; Vascular smooth muscle cell growth-promoting factor

Spondin 1 (SPON1)
CCC F397
HGNC 11252
MGI 2385287
PubMed 23471985
RGD 619918
UniProt Q9HCB6
Wiki SPON1
Spondin-1 is a protein contains 807 aminoacids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.The deduced 624-amino acid partial SPON1 protein shares 96.8% amino acid sequence identity with the rat F-spondin precursor across 624 residues.SPON1 expression in lung, lower expression in brain, heart, kidney, liver, and testis, and lowest expression in pancreas, skeletal muscle, and ovary; no expression was found in spleen. In vitro binding assays using mutated human proteins confirmed that SPON1 specifically bound to the central APP domain (CAPPD). SPON1 inhibited APP cleavage by BACE1, the primary beta-secretase involved in APP processing. Binding also impaired APP- and FE65-dependent transactivation of the chromosome remodeling factor TIP60 .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF397Hu01 Recombinant Spondin 1 (SPON1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF397Hu01 Polyclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IP.
MAF397Hu21 Monoclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IP.
Assay Kits SEF397Hu ELISA Kit for Spondin 1 (SPON1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF397Mu01 Recombinant Spondin 1 (SPON1) Positive Control; Immunogen; SDS-PAGE; WB.
RPF397Mu02 Recombinant Spondin 1 (SPON1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF397Mu01 Polyclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IP.
LAF397Mu71 Biotin-Linked Polyclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC.
PAF397Mu02 Polyclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IP.
Assay Kits SEF397Mu ELISA Kit for Spondin 1 (SPON1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spondin 1 (SPON1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spondin 1 (SPON1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spondin 1 (SPON1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spondin 1 (SPON1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spondin 1 (SPON1) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary."Arch. Biochem. Biophys. 390:93-100(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  6. "C-mannosylation and O-fucosylation of thrombospondin type 1 repeats."Mol. Cell. Proteomics 1:11-18(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Structure of the F-spondin reeler domain reveals a unique beta-sandwich fold with a deformable disulfide-bonded loop."Acta Crystallogr. D 64:1138-1145(2008) [PubMed] [Europe PMC] [Abstract]
  8. "The crystal structure of the heparin-binding reelin-N domain of f-spondin."J. Mol. Biol. 381:1213-1223(2008) [PubMed] [Europe PMC] [Abstract]