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Sirtuin 5 (SIRT5)

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SIR2L5; Silent Mating Type Information Regulation 2 Homolog 5; NAD-dependent protein deacylase sirtuin-5, mitochondrial; Regulatory protein SIR2 homolog 5; SIR2-like protein 5

Sirtuin 5 (SIRT5)
CCC E915
HGNC 14933
MGI 1915596
PubMed 22076378
RGD 1303285
UniProt Q9NXA8
Wiki SIRT5
SIRT5 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in two transcript variants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE915Hu01 Recombinant Sirtuin 5 (SIRT5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE915Hu01 Polyclonal Antibody to Sirtuin 5 (SIRT5) WB; IHC; ICC; IP.
MAE915Hu21 Monoclonal Antibody to Sirtuin 5 (SIRT5) WB; IHC; ICC; IP.
Assay Kits SEE915Hu ELISA Kit for Sirtuin 5 (SIRT5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE915Mu01 Recombinant Sirtuin 5 (SIRT5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE915Mu01 Polyclonal Antibody to Sirtuin 5 (SIRT5) WB; IHC; ICC; IP.
LAE915Mu71 Biotin-Linked Polyclonal Antibody to Sirtuin 5 (SIRT5) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Sirtuin 5 (SIRT5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sirtuin 5 (SIRT5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE915Ra01 Recombinant Sirtuin 5 (SIRT5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE915Ra01 Polyclonal Antibody to Sirtuin 5 (SIRT5) WB; IHC; ICC; IP.
LAE915Ra71 Biotin-Linked Polyclonal Antibody to Sirtuin 5 (SIRT5) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Sirtuin 5 (SIRT5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sirtuin 5 (SIRT5) ELISA Kit Customized Service Offer
  1. "Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity."Biochem. Biophys. Res. Commun. 260:273-279(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins."Mol. Biol. Cell 16:4623-4635(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5."J. Mol. Biol. 382:790-801(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms."Genes Cells 16:190-202(2011) [PubMed] [Europe PMC] [Abstract]
  10. "The first identification of lysine malonylation substrates and its regulatory enzyme."Mol. Cell. Proteomics 10:M111.012658.01-M111.012658.12(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition."PLoS ONE 7:E45098-E45098(2012) [PubMed] [Europe PMC] [Abstract]
  12. "SIRT5 desuccinylates and activates SOD1 to eliminate ROS."Biochem. Biophys. Res. Commun. 441:191-195(2013) [PubMed] [Europe PMC] [Abstract]
  13. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of human sirtuin homolog 5 in complex with NAD."Submitted (FEB-2006) to the PDB data bank
  16. "Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin."Structure 15:377-389(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase."Science 334:806-809(2011) [PubMed] [Europe PMC] [Abstract]
  18. "The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5)."J. Biol. Chem. 287:28307-28314(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Synthesis of carba-NAD and the structures of its ternary complexes with SIRT3 and SIRT5."J. Org. Chem. 77:7319-7329(2012) [PubMed] [Europe PMC] [Abstract]
  20. "A molecular mechanism for direct sirtuin activation by resveratrol."PLoS ONE 7:E49761-E49761(2012) [PubMed] [Europe PMC] [Abstract]