Interleukin 1 Epsilon (IL1e)

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IL1F6; IL36a; FIL1; FIL1(EPSILON); FIL1E; IL-1F6; IL1(EPSILON); Interleukin 36, Alpha; Interleukin 1 Family, Member 6

Interleukin 1 Epsilon (IL1e)
The cytokine interleukin-1 (IL1) elicits a wide array of biologic activities that initiate and promote the host response to injury or infection by activating a set of transcription factors, including NFKB and AP1, which in turn induce production of effectors of the inflammatory response. By searching an EST database for sequences resembling IL1 and probing a human genomic library, Smith et al. (2000) identified a cDNA encoding IL1F6, which they designated FIL1-epsilon. The deduced 158-amino acid protein, like FIL1-delta, contains neither a signal peptide nor a prodomain. It shares 48% sequence identity with FIL1-eta. PCR analyses detected expression in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Modeling indicated that FIL1-epsilon has a conserved 12-stranded beta-trefoil structure.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE843Hu01 Recombinant Interleukin 1 Epsilon (IL1e) Positive Control; Immunogen; SDS-PAGE; WB.
APE843Hu01 Active Interleukin 1 Epsilon (IL1e) Cell culture; Activity Assays.
Antibodies MAE843Hu21 Monoclonal Antibody to Interleukin 1 Epsilon (IL1e) WB; IHC; ICC; IP.
PAE843Hu01 Polyclonal Antibody to Interleukin 1 Epsilon (IL1e) WB; IHC; ICC; IP.
Assay Kits SCE843Hu CLIA Kit for Interleukin 1 Epsilon (IL1e) Chemiluminescent immunoassay for Antigen Detection.
SEE843Hu ELISA Kit for Interleukin 1 Epsilon (IL1e) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 1 Epsilon (IL1e) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 1 Epsilon (IL1e) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 1 Epsilon (IL1e) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 1 Epsilon (IL1e) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 1 Epsilon (IL1e) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 1 Epsilon (IL1e) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 1 Epsilon (IL1e) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 1 Epsilon (IL1e) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 1 Epsilon (IL1e) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 1 Epsilon (IL1e) ELISA Kit Customized Service Offer
  1. "Four new members expand the IL-1 superfamily."J. Biol. Chem. 275:1169-1175(2000) [PubMed] [Europe PMC] [Abstract]
  2. "A sequence-based map of the nine genes of the human interleukin-1 cluster."Genomics 79:718-725(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2."J. Immunol. 167:1440-1446(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs."J. Biol. Chem. 279:13677-13688(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry."Anal. Biochem. 354:279-289(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity."J. Biol. Chem. 286:42594-42602(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis."J. Invest. Dermatol. 131:2428-2437(2011) [PubMed] [Europe PMC] [Abstract]
  11. "IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin."J. Immunol. 192:6053-6061(2014) [PubMed] [Europe PMC] [Abstract]