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Xeroderma Pigmentosum, Complementation Group A (XPA)

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XP-A; XPAC; XP1; DNA repair protein complementing XP-A cells

Xeroderma Pigmentosum, Complementation Group A (XPA)
CCC E744
HGNC 12814
MGI 99135
PubMed 8197174
RGD 1308769
UniProt P23025
Wiki XPA
XPA encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. The deduced 273-amino acid protein has a calculated molecular mass of 31 kD. The human protein is 95% similar to the mouse protein and contains several alpha-helices and a zinc-finger motif, consistent with a DNA-binding protein. Two mRNAs, 1.3-1.4 kb and 1.0-1.1 kb, were detected in normal human cells. Sequence analysis identified a truncated XPA protein that could be translated from an ATG present at position 176, which retained sufficient function to partially restore the DNA repair defect in XPA cells. A 1.0-1.1-kb mouse Xpa mRNA was also identified.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE744Hu01 Recombinant Xeroderma Pigmentosum, Complementation Group A (XPA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE744Hu01 Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Xeroderma Pigmentosum, Complementation Group A (XPA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Xeroderma Pigmentosum, Complementation Group A (XPA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA) ELISA Kit Customized Service Offer
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  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic characterization of the human DNA excision repair-controlling gene XPAC."Gene 136:345-348(1993) [PubMed] [Europe PMC] [Abstract]
  5. "RPA involvement in the damage-recognition and incision steps of nucleotide excision repair."Nature 374:566-569(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of the human XPA promoter."Gene 166:341-342(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Identification and characterization of xpac protein, the gene product of the human XPAC (Xeroderma pigmentosum group A complementing) gene."J. Biol. Chem. 266:19786-19789(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Mutational analysis of the structure and function of the Xeroderma pigmentosum group A complementing protein. Identification of essential domains for nuclear localization and DNA excision repair."J. Biol. Chem. 267:12182-12187(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular analysis of Xeroderma pigmentosum group A gene."Jpn. J. Hum. Genet. 38:1-14(1993) [PubMed] [Europe PMC] [Abstract]
  10. "A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy."Hum. Mutat. 14:9-22(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation."Cancer Res. 66:2997-3005(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity."Cell Cycle 8:655-664(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase."Proc. Natl. Acad. Sci. U.S.A. 107:4890-4895(2010) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA."Nat. Struct. Biol. 5:701-706(1998) [PubMed] [Europe PMC] [Abstract]
  17. "Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies."Biochemistry 38:15116-15128(1999) [PubMed] [Europe PMC] [Abstract]
  18. "Molecular basis of group A Xeroderma pigmentosum: a missense mutation and two deletions located in a zinc finger consensus sequence of the XPAC gene."Hum. Genet. 88:603-607(1992) [PubMed] [Europe PMC] [Abstract]
  19. "Identification of splicing mutations of the last nucleotides of exons, a nonsense mutation, and a missense mutation of the XPAC gene as causes of group A Xeroderma pigmentosum."Mutat. Res. 273:203-212(1992) [PubMed] [Europe PMC] [Abstract]
  20. "Distribution of mutations in the human Xeroderma pigmentosum group A gene and their relationships to the functional regions of the DNA damage recognition protein."Hum. Mutat. 12:103-113(1998) [PubMed] [Europe PMC] [Abstract]