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FK506 Binding Protein 1A (FKBP1A)

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FKBP-12; FKBP1; FKBP12C; PKC12; PKCI2; Calstabin-1; Rotamase; 12 kDa FK506-binding protein; Peptidyl-prolyl cis-trans isomerase FKBP1A; Immunophilin FKBP12

FK506 Binding Protein 1A (FKBP1A)
CCC E641
HGNC 3711
MGI 95541
PubMed 23571217
RGD 2617
UniProt P62942
Wiki FKBP1A
FKBP1A is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. There is evidence of multiple alternatively spliced transcript variants for this gene, but the full length nature of some variants has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE641Hu01 Recombinant FK506 Binding Protein 1A (FKBP1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE641Hu01 Polyclonal Antibody to FK506 Binding Protein 1A (FKBP1A) WB; IHC; ICC; IP.
LAE641Hu71 Biotin-Linked Polyclonal Antibody to FK506 Binding Protein 1A (FKBP1A) WB; IHC; ICC.
LAE641Hu81 FITC-Linked Polyclonal Antibody to FK506 Binding Protein 1A (FKBP1A) WB; IHC; ICC; IF.
MAE641Hu21 Monoclonal Antibody to FK506 Binding Protein 1A (FKBP1A) WB; IHC; ICC; IP.
Assay Kits SEE641Hu ELISA Kit for FK506 Binding Protein 1A (FKBP1A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FK506 Binding Protein 1A (FKBP1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FK506 Binding Protein 1A (FKBP1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FK506 Binding Protein 1A (FKBP1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FK506 Binding Protein 1A (FKBP1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for FK506 Binding Protein 1A (FKBP1A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FK506 Binding Protein 1A (FKBP1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FK506 Binding Protein 1A (FKBP1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FK506 Binding Protein 1A (FKBP1A) Polyclonal Antibody Customized Service Offer
Assay Kits SEE641Ra ELISA Kit for FK506 Binding Protein 1A (FKBP1A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE641Bo01 Recombinant FK506 Binding Protein 1A (FKBP1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE641Bo01 Polyclonal Antibody to FK506 Binding Protein 1A (FKBP1A) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for FK506 Binding Protein 1A (FKBP1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for FK506 Binding Protein 1A (FKBP1A) ELISA Kit Customized Service Offer
  1. "Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin."Proc. Natl. Acad. Sci. U.S.A. 87:5440-5443(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and overexpression of the human FK506-binding protein FKBP."Nature 346:671-674(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Exon organization of the human FKBP-12 gene: correlation with structural and functional protein domains."Biochemistry 30:8512-8517(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Three distinct messenger RNAs can encode the human immunosuppressant-binding protein FKBP12."Gene 150:251-257(1994) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerase."J. Biol. Chem. 265:21011-21015(1990) [PubMed] [Europe PMC] [Abstract]
  8. "A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase."Nature 341:758-760(1989) [PubMed] [Europe PMC] [Abstract]
  9. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Mechanism of TGFbeta receptor inhibition by FKBP12."EMBO J. 16:3866-3876(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Further characterization of the type 3 ryanodine receptor (RyR3) purified from rabbit diaphragm."J. Biol. Chem. 274:17297-17308(1999) [PubMed] [Europe PMC] [Abstract]
  12. "FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor."J. Mol. Endocrinol. 36:569-579(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels."Arch. Biochem. Biophys. 517:37-42(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein."Biochemistry 30:4774-4789(1991) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin."Science 252:836-839(1991) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure of FK506 bound to FKBP-12."FEBS Lett. 302:89-96(1992) [PubMed] [Europe PMC] [Abstract]
  18. "1H, 13C, and 15N assignments and secondary structure of the FK506 binding protein when bound to ascomycin."Biopolymers 33:535-550(1993) [PubMed] [Europe PMC] [Abstract]
  19. "Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex."Science 252:839-842(1991) [PubMed] [Europe PMC] [Abstract]
  20. "Atomic structure of the rapamycin human immunophilin FKBP-12 complex."J. Am. Chem. Soc. 113:7433-7434(1991)
  21. "Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin."J. Mol. Biol. 229:105-124(1993) [PubMed] [Europe PMC] [Abstract]
  22. "Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12."Cell 96:425-436(1999) [PubMed] [Europe PMC] [Abstract]
  23. "X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies."J. Mol. Biol. 295:953-962(2000) [PubMed] [Europe PMC] [Abstract]