Conglutinin (CGN1)
Calcium-dependent lectin-like protein which binds to a yeast cell wall extract and immune complexes through the complement component (C3bi). It is capable of binding non-reducing terminal N-acetylglucosamine, mannose, and fucose residues.Collectins are soluble pattern recognition receptors belonging to the superfamily of collagen containing C-type lectins.Eight collectins have been identified including mannan-binding lectin (MBL), surfactant protein A (SP-A), surfactant protein D (SP-D), collectin liver 1 (CL-L1), collectin placenta 1 (CL-P1), conglutinin, collectin of 43 kDa (CL-43) and collectin of 46 kDa (CL-46).These molecules have been implicated as major modulators of the innate immune system where they have a key role in the first line of defense against invading microorganisms by binding to them so macrophages know to dispose of them.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Conglutinin (CGN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Conglutinin (CGN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Conglutinin (CGN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Conglutinin (CGN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Conglutinin (CGN1) ELISA Kit Customized Service Offer
  1. "Cloning and sequencing of a cDNA coding for bovine conglutinin."Biochem. Biophys. Res. Commun. 191:335-342(1993) [PubMed] [Europe PMC] [Abstract]
  2. "The cDNA cloning of conglutinin and identification of liver as a primary site of synthesis of conglutinin in members of the Bovidae."Biochem. J. 292:157-162(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Bovine conglutinin (BC) mRNA expressed in liver: cloning and characterization of the BC cDNA reveals strong homology to surfactant protein-D."Gene 141:277-281(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Bovine conglutinin gene exon structure reveals its evolutionary relationship to surfactant protein-D."J. Immunol. 153:173-180(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Gene organization and 5'-flanking region sequence of conglutinin: a C-type mammalian lectin containing a collagen-like domain."Biochem. Biophys. Res. Commun. 198:597-604(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of 954 bovine full-CDS cDNA sequences."BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Primary structure of bovine conglutinin, a member of the C-type animal lectin family."J. Biol. Chem. 266:2715-2723(1991) [PubMed] [Europe PMC] [Abstract]
  8. "The carbohydrate specificity of conglutinin and its homology to proteins in the hepatic lectin family."Biochem. Biophys. Res. Commun. 143:645-651(1987) [PubMed] [Europe PMC] [Abstract]
  9. "Localization of the receptor-binding site in the collectin family of proteins."Biochem. J. 293:15-19(1993) [PubMed] [Europe PMC] [Abstract]