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Ephrin B2 (EFNB2)

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EPLG5; HTKL; Htk-L; LERK5; HTK Ligand; Ligand Of Eph-Related Kinase 5; Eph-Related Receptor Tyrosine Kinase Ligand 5

Ephrin B2 (EFNB2)
CCC E112
HGNC 3227
MGI 105097
PubMed 10389937
RGD 1309497
UniProt P52799
Wiki EFNB2
Ephrin-B2 is a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.Binds to the receptor tyrosine kinases EPHB4 and EPHA3. May play a role in constraining the orientation of longitudinally projecting axons .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE112Hu01 Recombinant Ephrin B2 (EFNB2) Positive Control; Immunogen; SDS-PAGE; WB.
RPE112Hu02 Recombinant Ephrin B2 (EFNB2) Positive Control; Immunogen; SDS-PAGE; WB.
APE112Hu02 Active Ephrin B2 (EFNB2) Cell culture; Activity Assays.
Antibodies PAE112Hu01 Polyclonal Antibody to Ephrin B2 (EFNB2) WB; IHC; ICC; IP.
MAE112Hu21 Monoclonal Antibody to Ephrin B2 (EFNB2) WB; IHC; ICC; IP.
Assay Kits SEE112Hu ELISA Kit for Ephrin B2 (EFNB2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE112Mu01 Recombinant Ephrin B2 (EFNB2) Positive Control; Immunogen; SDS-PAGE; WB.
RPE112Mu02 Recombinant Ephrin B2 (EFNB2) Positive Control; Immunogen; SDS-PAGE; WB.
EPE112Mu61 Eukaryotic Ephrin B2 (EFNB2) Positive Control; Immunogen; SDS-PAGE; WB.
APE112Mu61 Active Ephrin B2 (EFNB2) Cell culture; Activity Assays.
Antibodies PAE112Mu01 Polyclonal Antibody to Ephrin B2 (EFNB2) WB; IHC; ICC; IP.
PAE112Mu02 Polyclonal Antibody to Ephrin B2 (EFNB2) WB; IHC; ICC; IP.
Assay Kits SEE112Mu ELISA Kit for Ephrin B2 (EFNB2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin B2 (EFNB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin B2 (EFNB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin B2 (EFNB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin B2 (EFNB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin B2 (EFNB2) ELISA Kit Customized Service Offer

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE112Fi01 Recombinant Ephrin B2 (EFNB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ephrin B2 (EFNB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin B2 (EFNB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin B2 (EFNB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin B2 (EFNB2) ELISA Kit Customized Service Offer
  1. "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases."Mol. Immunol. 32:1197-1205(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk."Proc. Natl. Acad. Sci. U.S.A. 92:1866-1870(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas."Clin. Cancer Res. 4:791-797(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells."J. Cell Sci. 116:2461-2470(2003) [PubMed] [Europe PMC] [Abstract]
  7. "EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus."Nature 436:401-405(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus."PLoS Pathog. 2:78-86(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity."J. Biol. Chem. 281:28185-28192(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2."Nat. Struct. Mol. Biol. 15:567-572(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Structural plasticity of EPH receptor A4 facilitates cross-class ephrin signaling."Structure 17:1386-1397(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity."J. Biol. Chem. 285:644-654(2010) [PubMed] [Europe PMC] [Abstract]