Arginase II (Arg2)

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Kidney-type arginase; Non-hepatic arginase

Arginase II (Arg2)

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. Arginase II is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD796Hu01 Recombinant Arginase II (Arg2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD796Hu01 Polyclonal Antibody to Arginase II (Arg2) WB; ICC; IHC-P; IHC-F; ELISA.
LAD796Hu71 Biotin-Linked Polyclonal Antibody to Arginase II (Arg2) WB; IHC; ICC.
LAD796Hu81 FITC-Linked Polyclonal Antibody to Arginase II (Arg2) WB; IHC; ICC; IF.
MAD796Hu21 Monoclonal Antibody to Arginase II (Arg2) WB; IHC
MAD796Hu22 Monoclonal Antibody to Arginase II (Arg2) WB; IHC; ICC; IP.
MAD796Hu23 Monoclonal Antibody to Arginase II (Arg2) WB; IHC; ICC; IP.
MAD796Hu24 Monoclonal Antibody to Arginase II (Arg2) WB; IHC; ICC; IP.
MAD796Hu27 Monoclonal Antibody to Arginase II (Arg2) WB; IHC; ICC; IP.
Assay Kits SED796Hu ELISA Kit for Arginase II (Arg2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD796Mu01 Recombinant Arginase II (Arg2) Positive Control; Immunogen; SDS-PAGE; WB.
RPD796Mu02 Recombinant Arginase II (Arg2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD796Mu01 Polyclonal Antibody to Arginase II (Arg2) WB; IHC; ICC; IP.
LAD796Mu81 FITC-Linked Polyclonal Antibody to Arginase II (Arg2) WB; IHC; ICC; IF.
LAD796Mu71 Biotin-Linked Polyclonal Antibody to Arginase II (Arg2) WB; IHC; ICC.
PAD796Mu02 Polyclonal Antibody to Arginase II (Arg2) WB; IHC; ICC; IP.
Assay Kits SED796Mu ELISA Kit for Arginase II (Arg2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD796Ra01 Recombinant Arginase II (Arg2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD796Ra01 Polyclonal Antibody to Arginase II (Arg2) WB; IHC; ICC; IP.
PAD796Ra02 Polyclonal Antibody to Arginase II (Arg2) WB; IHC; ICC; IP.
MAD796Ra22 Monoclonal Antibody to Arginase II (Arg2) WB; IHC; ICC; IP.
LAD796Ra71 Biotin-Linked Polyclonal Antibody to Arginase II (Arg2) WB; IHC; ICC.
Assay Kits SED796Ra ELISA Kit for Arginase II (Arg2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD796Bo01 Recombinant Arginase II (Arg2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD796Bo01 Polyclonal Antibody to Arginase II (Arg2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Arginase II (Arg2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arginase II (Arg2) ELISA Kit Customized Service Offer
  1. "Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line."FEBS Lett. 395:119-122(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of the human type II arginase gene."Genomics 38:118-123(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Human type II arginase: sequence analysis and tissue-specific expression."Gene 193:157-161(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Human arginase II: crystal structure and physiological role in male and female sexual arousal."Biochemistry 42:8445-8451(2003) [PubMed] [Europe PMC] [Abstract]