Lipolysis Stimulated Lipoprotein Receptor (LSR)

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LISCH7; ILDR3; LISCH; Lipolysis-Stimulated Remnant; Immunoglobulin-Like Domain Containing Receptor 3

Lipolysis Stimulated Lipoprotein Receptor (LSR)
LSR is a multimeric protein complex in the liver that undergoes conformational changes upon binding of free fatty acids, thereby revealing a binding site (s) that recognizes both apoB and apoE. Complete inactivation of the LSR gene is embryonic lethal in mice.LSR cooperates with the LDL receptor in the final hepatic processing of apoB-containing lipoproteins and represents a novel therapeutic target for the treatment of hyperlipidemia associated with obesity and atherosclerosis. The lipolysis-stimulated receptor (LSR) is a lipoprotein receptor primarily expressed in the liver and activated by free fatty acids. Antibodies inhibiting LSR functions showed that the receptor is a heterotrimer or tetramer consisting of 68-kDa (alpha) and 56-kDa (beta) subunits associated through disulfide bridges.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD744Hu01 Recombinant Lipolysis Stimulated Lipoprotein Receptor (LSR) Positive Control; Immunogen; SDS-PAGE; WB.
RPD744Hu02 Recombinant Lipolysis Stimulated Lipoprotein Receptor (LSR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD744Hu01 Polyclonal Antibody to Lipolysis Stimulated Lipoprotein Receptor (LSR) WB,IHC
LAD744Hu71 Biotin-Linked Polyclonal Antibody to Lipolysis Stimulated Lipoprotein Receptor (LSR) WB; IHC; ICC.
LAD744Hu81 FITC-Linked Polyclonal Antibody to Lipolysis Stimulated Lipoprotein Receptor (LSR) WB; IHC; ICC; IF.
MAD744Hu21 Monoclonal Antibody to Lipolysis Stimulated Lipoprotein Receptor (LSR) WB,IHC
LAD744Hu72 Biotin-Linked Monoclonal Antibody to Lipolysis Stimulated Lipoprotein Receptor (LSR) WB; IHC; ICC.
MAD744Hu22 Monoclonal Antibody to Lipolysis Stimulated Lipoprotein Receptor (LSR) WB; IHC
MAD744Hu23 Monoclonal Antibody to Lipolysis Stimulated Lipoprotein Receptor (LSR) WB; IHC; ICC; IP.
MAD744Hu24 Monoclonal Antibody to Lipolysis Stimulated Lipoprotein Receptor (LSR) WB; IHC; ICC; IP.
MAD744Hu25 Monoclonal Antibody to Lipolysis Stimulated Lipoprotein Receptor (LSR) WB; IHC; ICC; IP.
MAD744Hu27 Monoclonal Antibody to Lipolysis Stimulated Lipoprotein Receptor (LSR) WB
Assay Kits SED744Hu ELISA Kit for Lipolysis Stimulated Lipoprotein Receptor (LSR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD744Mu01 Recombinant Lipolysis Stimulated Lipoprotein Receptor (LSR) Positive Control; Immunogen; SDS-PAGE; WB.
RPD744Mu02 Recombinant Lipolysis Stimulated Lipoprotein Receptor (LSR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD744Mu01 Polyclonal Antibody to Lipolysis Stimulated Lipoprotein Receptor (LSR) WB,ICC/IF
PAD744Mu02 Polyclonal Antibody to Lipolysis Stimulated Lipoprotein Receptor (LSR) WB; IHC; ICC; IP.
Assay Kits SED744Mu ELISA Kit for Lipolysis Stimulated Lipoprotein Receptor (LSR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lipolysis Stimulated Lipoprotein Receptor (LSR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lipolysis Stimulated Lipoprotein Receptor (LSR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lipolysis Stimulated Lipoprotein Receptor (LSR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lipolysis Stimulated Lipoprotein Receptor (LSR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lipolysis Stimulated Lipoprotein Receptor (LSR) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]