Interleukin 17C (IL17C)

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Cytokine CX2

Interleukin 17C (IL17C)
Interleukin 17C is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. Northern blot analysis detected an 800-bp IL17B mRNA in adult pancreas, small intestine, and stomach, whereas IL17C mRNA was not detected in several adult tissues. No expression of IL17B or IL17C mRNA was found in activated T cells. The authors found that IL17B and IL17C differ from IL17 in their patterns of expression and biologic activities. These findings, coupled with the lack of interaction with the known IL17 receptor, suggested an expanded role for the IL17 family in the proinflammatory immune response.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD347Hu01 Recombinant Interleukin 17C (IL17C) Positive Control; Immunogen; SDS-PAGE; WB.
APD347Hu01 Active Interleukin 17C (IL17C) Cell culture; Activity Assays.
Antibodies PAD347Hu01 Polyclonal Antibody to Interleukin 17C (IL17C) WB; IHC; ICC; IP.
MAD347Hu21 Monoclonal Antibody to Interleukin 17C (IL17C) WB; IHC; ICC; IP.
Assay Kits SCD347Hu CLIA Kit for Interleukin 17C (IL17C) Chemiluminescent immunoassay for Antigen Detection.
SED347Hu ELISA Kit for Interleukin 17C (IL17C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD347Mu01 Recombinant Interleukin 17C (IL17C) Positive Control; Immunogen; SDS-PAGE; WB.
RPD347Mu02 Recombinant Interleukin 17C (IL17C) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD347Mu01 Polyclonal Antibody to Interleukin 17C (IL17C) WB; IHC; ICC; IP.
PAD347Mu02 Polyclonal Antibody to Interleukin 17C (IL17C) WB; IHC; ICC; IP.
Assay Kits SED347Mu ELISA Kit for Interleukin 17C (IL17C) Enzyme-linked immunosorbent assay for Antigen Detection.
SCD347Mu CLIA Kit for Interleukin 17C (IL17C) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD347Ra01 Recombinant Interleukin 17C (IL17C) Positive Control; Immunogen; SDS-PAGE; WB.
EPD347Ra61 Eukaryotic Interleukin 17C (IL17C) Positive Control; Immunogen; SDS-PAGE; WB.
APD347Ra61 Active Interleukin 17C (IL17C) Cell culture; Activity Assays.
Antibodies PAD347Ra01 Polyclonal Antibody to Interleukin 17C (IL17C) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interleukin 17C (IL17C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 17C (IL17C) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family."Proc. Natl. Acad. Sci. U.S.A. 97:773-778(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens."Nat. Immunol. 12:1151-1158(2011) [PubMed] [Europe PMC] [Abstract]
  5. "IL-17C regulates the innate immune function of epithelial cells in an autocrine manner." Nat. Immunol. 12:1159-1166(2011) [PubMed] [Europe PMC] [Abstract]