Interleukin 17D (IL17D)

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Interleukin-27

Interleukin 17D (IL17D)
Interleukin 17D is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent.The predicted 202-amino acid protein, the longest in the IL17 family, contains a signal peptide, conserved cysteines that allow homodimer formation, and a unique extended C-terminal domain. RT-PCR analysis showed high expression in skeletal muscle, brain, adipose, heart, lung, and pancreas, with lower expression in bone marrow, fetal liver, kidney, leukocytes, liver, lymph node, placenta, spleen, thymus, tonsil, resting CD4 -positive T cells, and resting CD19 -positive B cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD346Hu01 Recombinant Interleukin 17D (IL17D) Positive Control; Immunogen; SDS-PAGE; WB.
APD346Hu01 Active Interleukin 17D (IL17D) Cell culture; Activity Assays.
Antibodies PAD346Hu01 Polyclonal Antibody to Interleukin 17D (IL17D) WB; IHC; ICC; IP.
MAD346Hu21 Monoclonal Antibody to Interleukin 17D (IL17D) WB; IHC; ICC; IP.
Assay Kits SED346Hu ELISA Kit for Interleukin 17D (IL17D) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD346Mu01 Recombinant Interleukin 17D (IL17D) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Interleukin 17D (IL17D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 17D (IL17D) Polyclonal Antibody Customized Service Offer
Assay Kits SED346Mu ELISA Kit for Interleukin 17D (IL17D) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD346Ra01 Recombinant Interleukin 17D (IL17D) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD346Ra01 Polyclonal Antibody to Interleukin 17D (IL17D) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interleukin 17D (IL17D) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 17D (IL17D) ELISA Kit Customized Service Offer
  1. "IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis."J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 169:642-646(2002)
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]