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Cytochrome C Oxidase Subunit I (COX1)

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MT-CO1; MTCO1; COI; COXI; Mitochondrially Encoded Cytochrome C Oxidase I; Cytochrome c oxidase polypeptide I

Cytochrome C Oxidase Subunit I (COX1)
CCC D283
HGNC 7419
MGI 102504
PubMed 23362268
RGD 621871
UniProt P00395
Wiki MT-CO1
MT-CO1 belongs to cytochrome c oxidase subunit I protein family. It is often used in DNA barcoding, because its mutation rate is often fast enough to distinguish closely related species. In most if not all seed plants, however, the rate of evolution of cox1 is very slow.
The enzyme complex consists of 3-4 subunits (prokaryotes) up to 13 polypeptides (mammals) of which only the catalytic subunit (equivalent to mammalian subunit I (CO I)) is found in all heme-copper respiratory oxidases. The presence of a bimetallic centre (formed by a high-spin heme and copper B) as well as a low-spin heme, both ligated to six conserved histidine residues near the outer side of four transmembrane spans within CO I is common to all family members.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome C Oxidase Subunit I (COX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome C Oxidase Subunit I (COX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome C Oxidase Subunit I (COX1) Polyclonal Antibody Customized Service Offer
Assay Kits SED283Hu ELISA Kit for Cytochrome C Oxidase Subunit I (COX1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome C Oxidase Subunit I (COX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome C Oxidase Subunit I (COX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome C Oxidase Subunit I (COX1) Polyclonal Antibody Customized Service Offer
Assay Kits SED283Mu ELISA Kit for Cytochrome C Oxidase Subunit I (COX1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome C Oxidase Subunit I (COX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome C Oxidase Subunit I (COX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome C Oxidase Subunit I (COX1) Polyclonal Antibody Customized Service Offer
Assay Kits SED283Ra ELISA Kit for Cytochrome C Oxidase Subunit I (COX1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  15. "Introducing a novel human mtDNA mutation into the Paracoccus denitrificans COX I gene explains functional deficits in a patient."Neurogenetics 7:51-57(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission."Proc. Natl. Acad. Sci. U.S.A. 103:714-719(2006) [PubMed] [Europe PMC] [Abstract]
  17. "A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidase."Proc. Natl. Acad. Sci. U.S.A. 106:3402-3407(2009) [PubMed] [Europe PMC] [Abstract]