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Troponin I Type 1, Slow Skeletal (TNNI1)

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TNN1; Troponin I, slow-twitch isoform

Troponin I Type 1, Slow Skeletal (TNNI1)
CCC D229
HGNC 11945
MGI 105073
PubMed 20145300
RGD 621765
UniProt P19237
Wiki TNNI1
TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein.
TNNI1 is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD229Hu01 Recombinant Troponin I Type 1, Slow Skeletal (TNNI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD229Hu01 Polyclonal Antibody to Troponin I Type 1, Slow Skeletal (TNNI1) WB
LAD229Hu71 Biotin-Linked Polyclonal Antibody to Troponin I Type 1, Slow Skeletal (TNNI1) WB; IHC; ICC.
LAD229Hu81 FITC-Linked Polyclonal Antibody to Troponin I Type 1, Slow Skeletal (TNNI1) WB; IHC; ICC; IF.
MAD229Hu21 Monoclonal Antibody to Troponin I Type 1, Slow Skeletal (TNNI1) WB; IHC; ICC; IP.
Assay Kits SED229Hu ELISA Kit for Troponin I Type 1, Slow Skeletal (TNNI1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD229Mu01 Recombinant Troponin I Type 1, Slow Skeletal (TNNI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD229Mu01 Polyclonal Antibody to Troponin I Type 1, Slow Skeletal (TNNI1) WB; IHC; ICC; IP.
LAD229Mu71 Biotin-Linked Polyclonal Antibody to Troponin I Type 1, Slow Skeletal (TNNI1) WB; IHC; ICC.
MAD229Mu21 Monoclonal Antibody to Troponin I Type 1, Slow Skeletal (TNNI1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Troponin I Type 1, Slow Skeletal (TNNI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Troponin I Type 1, Slow Skeletal (TNNI1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD229Ra01 Recombinant Troponin I Type 1, Slow Skeletal (TNNI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD229Ra01 Polyclonal Antibody to Troponin I Type 1, Slow Skeletal (TNNI1) WB
LAD229Ra71 Biotin-Linked Polyclonal Antibody to Troponin I Type 1, Slow Skeletal (TNNI1) WB; IHC; ICC.
LAD229Ra81 FITC-Linked Polyclonal Antibody to Troponin I Type 1, Slow Skeletal (TNNI1) WB; IHC; ICC; IF.
MAD229Ra21 Monoclonal Antibody to Troponin I Type 1, Slow Skeletal (TNNI1) WB; IHC; ICC; IP.
Assay Kits SED229Ra ELISA Kit for Troponin I Type 1, Slow Skeletal (TNNI1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I."Genomics 7:346-357(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and expression of the human slow twitch skeletal muscle troponin I gene."J. Biol. Chem. 269:10651-10659(1994) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]