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Sjogren Syndrome Antigen A1 (SSA1)

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RO52; RNF81; RO52; TRIM21; 52kDa,Ribonucleoprotein Autoantigen SS-A/Ro; Tripartite Motif-Containing 21; Autoantigen Ro, 52kDa; RING finger protein 81

Sjogren Syndrome Antigen A1 (SSA1)
CCC D200
HGNC 11312
MGI 106657
PubMed 21905010
RGD 1305795
UniProt P19474

Diagnosing Sjögren’s syndrome is complicated by the range of symptoms a patient may manifest, and the similarity between symptoms from Sjögren's syndrome and those caused by other conditions. Nevertheless, the combination of several tests can lead to a diagnosis of Sjögren's syndrome.

Blood tests can be done to determine if a patient has high levels of antibodies that are indicative of the condition, such as anti-nuclear antibody (ANA) and rheumatoid factor (because SS frequently occurs secondary to rheumatoid arthritis), which are associated with autoimmune diseases. Typical Sjögren's syndrome ANA patterns are SSA/Ro and SSB/La, of which SSB/La is far more specific; SSA/Ro is associated with numerous other autoimmune conditions but are often present in Sjögren's.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD200Hu01 Recombinant Sjogren Syndrome Antigen A1 (SSA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD200Hu01 Polyclonal Antibody to Sjogren Syndrome Antigen A1 (SSA1) WB; IHC; ICC; IP.
Assay Kits SED200Hu ELISA Kit for Sjogren Syndrome Antigen A1 (SSA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD200Mu01 Recombinant Sjogren Syndrome Antigen A1 (SSA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD200Mu01 Polyclonal Antibody to Sjogren Syndrome Antigen A1 (SSA1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Sjogren Syndrome Antigen A1 (SSA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sjogren Syndrome Antigen A1 (SSA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD200Ra01 Recombinant Sjogren Syndrome Antigen A1 (SSA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD200Ra01 Polyclonal Antibody to Sjogren Syndrome Antigen A1 (SSA1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Sjogren Syndrome Antigen A1 (SSA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sjogren Syndrome Antigen A1 (SSA1) ELISA Kit Customized Service Offer
  1. "Protein heterogeneity in the human Ro/SSA ribonucleoproteins. The 52- and 60-kD Ro/SSA autoantigens are encoded by separate genes."J. Clin. Invest. 87:177-186(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen."J. Clin. Invest. 87:68-76(1991) [PubMed] [Europe PMC] [Abstract]
  3. "The location of a disease-associated polymorphism and genomic structure of the human 52-kDa Ro/SSA locus (SSA1)."Genomics 24:541-548(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Structural differences between the human and mouse 52-kD Ro autoantigens associated with poorly conserved autoantibody activity across species."Clin. Exp. Immunol. 104:255-263(1996) [PubMed] [Europe PMC] [Abstract]
  5. "A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region."Genomics 55:164-175(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart."J. Exp. Med. 182:983-992(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen."J. Immunol. 156:4484-4491(1996) [PubMed] [Europe PMC] [Abstract]
  10. "Association of stress proteins with autoantigens: a possible mechanism for triggering autoimmunity?"Clin. Exp. Immunol. 132:193-200(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Autoantigen Ro52 is an E3 ubiquitin ligase."Biochem. Biophys. Res. Commun. 339:415-421(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity."Biochem. Biophys. Res. Commun. 339:731-736(2006) [PubMed] [Europe PMC] [Abstract]
  13. "UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself."Biochem. Biophys. Res. Commun. 342:253-258(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein."Mol. Cell. Biol. 26:5994-6004(2006) [PubMed] [Europe PMC] [Abstract]
  15. "SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity."Biochem. Biophys. Res. Commun. 370:195-199(2008) [PubMed] [Europe PMC] [Abstract]
  16. "The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide."Exp. Cell Res. 314:3605-3613(2008) [PubMed] [Europe PMC] [Abstract]
  17. "The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3."J. Immunol. 181:1780-1786(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Ro52 functionally interacts with IgG1 and regulates its quality control via the ERAD system."Mol. Immunol. 45:2045-2054(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling."J. Biochem. 146:821-832(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Extraordinary antigenicity of the human Ro52 autoantigen."Am. J. Transl. Res. 2:145-155(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Dynamic movements of Ro52 cytoplasmic bodies along microtubules."Histochem. Cell Biol. 133:273-284(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]