Interleukin 1 Eta (IL1h)

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IL1F8; IL36b; FIL1; FIL1-(ETA); FIL1H; IL-1F8; IL-1H2; IL1-ETA; IL1H2; Interleukin 36, Beta; Interleukin-1 Family Member 8; Interleukin-1 homolog 2

Interleukin 1 Eta (IL1h)
Interleukin-1 family member 8 is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.The deduced 157-amino acid protein, like FIL1-delta, contains neither a signal peptide nor a prodomain. It shares 46% sequence identity with FIL1-epsilon. PCR analyses detected expression in tonsil, bone marrow, heart, placenta, lung, testis, and colon but not in other tissues or in any hematopoietic cell lines. Modeling indicated that FIL1-eta has a conserved 12-stranded beta-trefoil structure.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD134Hu01 Recombinant Interleukin 1 Eta (IL1h) Positive Control; Immunogen; SDS-PAGE; WB.
APD134Hu01 Active Interleukin 1 Eta (IL1h) Cell culture; Activity Assays.
Antibodies PAD134Hu01 Polyclonal Antibody to Interleukin 1 Eta (IL1h) WB; IHC; ICC; IP.
MAD134Hu21 Monoclonal Antibody to Interleukin 1 Eta (IL1h) WB; IHC; ICC; IP.
Assay Kits SED134Hu ELISA Kit for Interleukin 1 Eta (IL1h) Enzyme-linked immunosorbent assay for Antigen Detection.
SCD134Hu CLIA Kit for Interleukin 1 Eta (IL1h) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 1 Eta (IL1h) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 1 Eta (IL1h) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 1 Eta (IL1h) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 1 Eta (IL1h) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 1 Eta (IL1h) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 1 Eta (IL1h) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 1 Eta (IL1h) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 1 Eta (IL1h) Polyclonal Antibody Customized Service Offer
Assay Kits SED134Ra ELISA Kit for Interleukin 1 Eta (IL1h) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Identification and initial characterization of four novel members of the interleukin-1 family."J. Biol. Chem. 275:10308-10314(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Four new members expand the IL-1 superfamily."J. Biol. Chem. 275:1169-1175(2000) [PubMed] [Europe PMC] [Abstract]
  3. "A sequence-based map of the nine genes of the human interleukin-1 cluster."Genomics 79:718-725(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes."Arthritis Res. Ther. 8:R80-R80(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The effect of the interleukin-1 cytokine family members IL-1F6 and IL-1F8 on adipocyte differentiation."Obesity 18:2234-2236(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity."J. Biol. Chem. 286:42594-42602(2011) [PubMed] [Europe PMC] [Abstract]
  9. "IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression."J. Immunol. 186:2613-2622(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis."J. Invest. Dermatol. 131:2428-2437(2011) [PubMed] [Europe PMC] [Abstract]
  11. "IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin."J. Immunol. 192:6053-6061(2014) [PubMed] [Europe PMC] [Abstract]