Fibroblast Growth Factor 8, Androgen Induced (FGF8)

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AIGF; HBGF8; Androgen-induced growth factor; Heparin-binding growth factor 8

Fibroblast Growth Factor 8, Androgen Induced (FGF8)
Fibroblast growth factor 8 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. The alternative splicing of this gene results in four transcript variants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC908Hu01 Recombinant Fibroblast Growth Factor 8, Androgen Induced (FGF8) Positive Control; Immunogen; SDS-PAGE; WB.
CPC908Hu21 OVA Conjugated Fibroblast Growth Factor 8, Androgen Induced (FGF8) Immunogen; SDS-PAGE; WB.
APC908Hu01 Active Fibroblast Growth Factor 8, Androgen Induced (FGF8) Cell culture; Activity Assays.
RPC908Hu02 Recombinant Fibroblast Growth Factor 8, Androgen Induced (FGF8) Positive Control; Immunogen; SDS-PAGE; WB.
RPC908Hu03 Recombinant Fibroblast Growth Factor 8, Androgen Induced (FGF8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC908Hu01 Polyclonal Antibody to Fibroblast Growth Factor 8, Androgen Induced (FGF8) WB; IHC; ICC; IP.
MAC908Hu21 Monoclonal Antibody to Fibroblast Growth Factor 8, Androgen Induced (FGF8) WB; IHC; ICC; IP.
PAC908Hu08 Polyclonal Antibody to Fibroblast Growth Factor 8, Androgen Induced (FGF8) WB; IHC; ICC; IP.
Assay Kits SEC908Hu ELISA Kit for Fibroblast Growth Factor 8, Androgen Induced (FGF8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC908Mu01 Recombinant Fibroblast Growth Factor 8, Androgen Induced (FGF8) Positive Control; Immunogen; SDS-PAGE; WB.
RPC908Mu02 Recombinant Fibroblast Growth Factor 8, Androgen Induced (FGF8) Positive Control; Immunogen; SDS-PAGE; WB.
RPC908Mu03 Recombinant Fibroblast Growth Factor 8, Androgen Induced (FGF8) Positive Control; Immunogen; SDS-PAGE; WB.
RPC908Mu04 Recombinant Fibroblast Growth Factor 8, Androgen Induced (FGF8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC908Mu01 Polyclonal Antibody to Fibroblast Growth Factor 8, Androgen Induced (FGF8) WB; IHC; ICC; IP.
PAC908Mu02 Polyclonal Antibody to Fibroblast Growth Factor 8, Androgen Induced (FGF8) WB; IHC; ICC; IP.
Assay Kits SEC908Mu ELISA Kit for Fibroblast Growth Factor 8, Androgen Induced (FGF8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fibroblast Growth Factor 8, Androgen Induced (FGF8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fibroblast Growth Factor 8, Androgen Induced (FGF8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fibroblast Growth Factor 8, Androgen Induced (FGF8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fibroblast Growth Factor 8, Androgen Induced (FGF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibroblast Growth Factor 8, Androgen Induced (FGF8) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC908Eq01 Recombinant Fibroblast Growth Factor 8, Androgen Induced (FGF8) Positive Control; Immunogen; SDS-PAGE; WB.
RPC908Eq02 Recombinant Fibroblast Growth Factor 8, Androgen Induced (FGF8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC908Eq01 Polyclonal Antibody to Fibroblast Growth Factor 8, Androgen Induced (FGF8) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Fibroblast Growth Factor 8, Androgen Induced (FGF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibroblast Growth Factor 8, Androgen Induced (FGF8) ELISA Kit Customized Service Offer
  1. "Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties."FEBS Lett. 363:226-230(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of human FGF8 alternative messenger RNA forms."Cell Growth Differ. 7:1425-1434(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and sequence of human FGF8."Genomics 35:253-257(1996) [PubMed] [Europe PMC] [Abstract]
  4. "The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells."Oncogene 13:47-53(1996) [PubMed] [Europe PMC] [Abstract]
  5. "A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma."Dig. Dis. Sci. 46:1016-1021(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Receptor specificity of the fibroblast growth factor family."J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Fibroblast growth factor signalling: from development to cancer."Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Senataxin modulates neurite growth through fibroblast growth factor 8 signalling."Brain 134:1808-1828(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain."Genes Dev. 20:185-198(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice." J. Clin. Invest. 118:2822-2831(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism." Am. J. Hum. Genet. 92:725-743(2013) [PubMed] [Europe PMC] [Abstract]