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Osteosarcoma Amplified 9 (OS9)

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ERLEC2; Amplified In Osteosarcoma; Endoplasmic Reticulum Lectin 2; Erlectin 2

Osteosarcoma Amplified 9 (OS9)
CCC C693
HGNC 16994
MGI 1924301
PubMed 21523322
RGD 1359574
UniProt Q13438
Wiki OS9_(gene
Protein OS-9 is a protein that is highly expressed in osteosarcomas.This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
The deduced 667-amino acid protein has a calculated molecular mass of 75.6 kD. OS9 contains an N-terminal leader peptide, a 211-amino acid hydrophilic region with 8 cysteines, and an acidic region with multiple predicted hydrophilic helices. It also has a putative nuclear targeting signal. The hydrophilic region of OS9 is highly conserved in human, S. cerevisiae, and C. elegans, with complete conservation of the 8 cysteines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC693Hu01 Recombinant Osteosarcoma Amplified 9 (OS9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC693Hu01 Polyclonal Antibody to Osteosarcoma Amplified 9 (OS9) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Osteosarcoma Amplified 9 (OS9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Osteosarcoma Amplified 9 (OS9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC693Mu01 Recombinant Osteosarcoma Amplified 9 (OS9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC693Mu01 Polyclonal Antibody to Osteosarcoma Amplified 9 (OS9) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Osteosarcoma Amplified 9 (OS9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Osteosarcoma Amplified 9 (OS9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC693Ra01 Recombinant Osteosarcoma Amplified 9 (OS9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC693Ra01 Polyclonal Antibody to Osteosarcoma Amplified 9 (OS9) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Osteosarcoma Amplified 9 (OS9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Osteosarcoma Amplified 9 (OS9) ELISA Kit Customized Service Offer
  1. "Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas."Mol. Carcinog. 15:270-275(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization of the OS-9 gene amplified in human sarcomas."J. Biochem. 122:1190-1195(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines."J. Biochem. 123:876-882(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers."Genomics 42:295-301(1997) [PubMed] [Europe PMC] [Abstract]
  8. "OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum."J. Biol. Chem. 282:36561-36570(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal."J. Biol. Chem. 283:16446-16454(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP."J. Biol. Chem. 283:20914-20924(2008) [PubMed] [Europe PMC] [Abstract]
  11. "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD."Nat. Cell Biol. 10:272-282(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans."J. Biol. Chem. 284:17061-17068(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins."J. Mol. Biol. 385:1032-1042(2009) [PubMed] [Europe PMC] [Abstract]
  14. "DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation."Mol. Immunol. 47:1963-1973(2010) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Structural basis for oligosaccharide recognition of misfolded glycoproteins by OS-9 in ER-associated degradation."Mol. Cell 40:905-916(2010) [PubMed] [Europe PMC] [Abstract]