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Furin (FUR)

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PACE; PCSK3; SPC1; Paired Basic Amino Acid Cleaving Enzyme; Dibasic-processing enzyme

Furin (FUR)
CCC C494
HGNC 8568
MGI 97513
PubMed 12360192
RGD 3274
UniProt P09958
Wiki Furin

Furin is an enzyme which belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. A furin-like pro-protein convertase has been implicated in the processing of RGMc (also called hemojuvelin ), a gene involved in a severe iron-overload disorder called juvenile hemochromatosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC494Hu01 Recombinant Furin (FUR) Positive Control; Immunogen; SDS-PAGE; WB.
RPC494Hu02 Recombinant Furin (FUR) Positive Control; Immunogen; SDS-PAGE; WB.
RPC494Hu03 Recombinant Furin (FUR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC494Hu01 Polyclonal Antibody to Furin (FUR) WB; IHC; ICC; IP.
MAC494Hu22 Monoclonal Antibody to Furin (FUR) WB; IHC; ICC; IP.
PAC494Hu02 Polyclonal Antibody to Furin (FUR) WB; IHC; ICC; IP.
LAC494Hu71 Biotin-Linked Polyclonal Antibody to Furin (FUR) WB; IHC; ICC.
PAC494Hu03 Polyclonal Antibody to Furin (FUR) WB; IHC; ICC; IP.
Assay Kits SEC494Hu ELISA Kit for Furin (FUR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC494Mu01 Recombinant Furin (FUR) Positive Control; Immunogen; SDS-PAGE; WB.
RPC494Mu02 Recombinant Furin (FUR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC494Mu01 Polyclonal Antibody to Furin (FUR) WB; IHC; ICC; IP.
LAC494Mu71 Biotin-Linked Polyclonal Antibody to Furin (FUR) WB; IHC; ICC.
PAC494Mu02 Polyclonal Antibody to Furin (FUR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Furin (FUR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Furin (FUR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC494Ra01 Recombinant Furin (FUR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAC494Ra21 Monoclonal Antibody to Furin (FUR) WB; IHC; ICC; IP.
PAC494Ra01 Polyclonal Antibody to Furin (FUR) WB; IHC; ICC; IP.
Assay Kits SEC494Ra ELISA Kit for Furin (FUR) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2."Nucleic Acids Res. 18:664-664(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site."Proc. Natl. Acad. Sci. U.S.A. 87:9378-9382(1990) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA and gene structure for a human subtilisin-like protease with cleavage specificity for paired basic amino acid residues."DNA Cell Biol. 10:319-328(1991) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Nucleotide sequence analysis of the human fur gene."Nucleic Acids Res. 17:7101-7102(1989) [PubMed] [Europe PMC] [Abstract]
  6. "Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein."EMBO J. 5:2197-2202(1986) [PubMed] [Europe PMC] [Abstract]
  7. "A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells."Biochem. Biophys. Res. Commun. 195:1019-1026(1993) [PubMed] [Europe PMC] [Abstract]
  8. "A second mutant allele of furin in the processing-incompetent cell line, LoVo. Evidence for involvement of the homo B domain in autocatalytic activation."J. Biol. Chem. 270:26565-26569(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage."J. Biol. Chem. 267:14304-14308(1992) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases."Eur. J. Biochem. 222:255-266(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail."EMBO J. 14:5869-5883(1995) [PubMed] [Europe PMC] [Abstract]
  13. "PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic."EMBO J. 20:2191-2201(2001) [PubMed] [Europe PMC] [Abstract]