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Cartilage Intermediate Layer Protein (CILP)

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Nucleotide Pyrophosphohydrolase; Cartilage intermediate-layer protein

Cartilage Intermediate Layer Protein (CILP)
CCC C382
HGNC 1980
MGI 2444507
PubMed 12483726
RGD 1305124
UniProt O75339
Wiki CILP

Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. The synthesis of cartilage intermediate layer protein (CILP), which was identified and purified from human articular cartilage, increases in early osteoarthrosis cartilage. The C-terminal 460 amino acids of the protein show 90% similarity to the pig ectonucleotide pyrophosphohydrolase NTPPHase; this region is preceded by a furin protease consensus cleavage site. Thus, the CILP gene is thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase.The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC382Hu01 Recombinant Cartilage Intermediate Layer Protein (CILP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC382Hu01 Polyclonal Antibody to Cartilage Intermediate Layer Protein (CILP) WB; IHC; ICC; IP.
PAC382Hu02 Polyclonal Antibody to Cartilage Intermediate Layer Protein (CILP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cartilage Intermediate Layer Protein (CILP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cartilage Intermediate Layer Protein (CILP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC382Mu01 Recombinant Cartilage Intermediate Layer Protein (CILP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC382Mu01 Polyclonal Antibody to Cartilage Intermediate Layer Protein (CILP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cartilage Intermediate Layer Protein (CILP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cartilage Intermediate Layer Protein (CILP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cartilage Intermediate Layer Protein (CILP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cartilage Intermediate Layer Protein (CILP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cartilage Intermediate Layer Protein (CILP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cartilage Intermediate Layer Protein (CILP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cartilage Intermediate Layer Protein (CILP) ELISA Kit Customized Service Offer
  1. "Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase."J. Biol. Chem. 273:23469-23475(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization, mapping, and polymorphisms of the gene encoding human cartilage intermediate layer protein (CILP)."J. Hum. Genet. 44:203-205(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The human CILP gene: exon/intron organization and chromosomal mapping."Matrix Biol. 18:445-454(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age."J. Biol. Chem. 273:23463-23468(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Up-regulated expression of cartilage intermediate-layer protein and ANK in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease."Arthritis Rheum. 46:3218-3229(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Implication of cartilage intermediate layer protein in cartilage destruction in subsets of patients with osteoarthritis and rheumatoid arthritis."Arthritis Rheum. 44:838-845(2001) [PubMed] [Europe PMC] [Abstract]
  11. "One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist."Arthritis Rheum. 48:1302-1314(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Characterisation of cartilage intermediate layer protein (CILP)-induced arthropathy in mice."Ann. Rheum. Dis. 63:252-258(2004) [PubMed] [Europe PMC] [Abstract]
  13. "The prevalence of autoantibodies against cartilage intermediate layer protein, YKL-39, osteopontin, and cyclic citrullinated peptide in patients with early-stage knee osteoarthritis: evidence of a variety of autoimmune processes."Rheumatol. Int. 26:35-41(2005) [PubMed] [Europe PMC] [Abstract]
  14. "A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease."Nat. Genet. 37:607-612(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]