Carboxylesterase 1 (CES1)

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ACAT; CEH; CES2; HMSE1; PCE1; SES1; TGH; Retinyl ester hydrolase; Serine esterase 1; Triacylglycerol hydrolase; Egasyn; Cocaine carboxylesterase; Liver Carboxylesterase 1

Carboxylesterase 1 (CES1)

Carboxylesterase 1 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters.

This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds. Carboxylesterase deficiency may be associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia. Three transcript variants encoding three different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC374Hu01 Recombinant Carboxylesterase 1 (CES1) Positive Control; Immunogen; SDS-PAGE; WB.
APC374Hu01 Active Carboxylesterase 1 (CES1) Cell culture; Activity Assays.
EPC374Hu61 Eukaryotic Carboxylesterase 1 (CES1) Positive Control; Immunogen; SDS-PAGE; WB.
APC374Hu61 Active Carboxylesterase 1 (CES1) Cell culture; Activity Assays.
Antibodies PAC374Hu01 Polyclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IP.
Assay Kits SEC374Hu ELISA Kit for Carboxylesterase 1 (CES1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC374Mu01 Recombinant Carboxylesterase 1 (CES1) Positive Control; Immunogen; SDS-PAGE; WB.
APC374Mu01 Active Carboxylesterase 1 (CES1) Cell culture; Activity Assays.
RPC374Mu02 Recombinant Carboxylesterase 1 (CES1) Positive Control; Immunogen; SDS-PAGE; WB.
EPC374Mu61 Eukaryotic Carboxylesterase 1 (CES1) Positive Control; Immunogen; SDS-PAGE; WB.
APC374Mu02 Active Carboxylesterase 1 (CES1) Cell culture; Activity Assays.
APC374Mu61 Active Carboxylesterase 1 (CES1) Cell culture; Activity Assays.
Antibodies PAC374Mu01 Polyclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Carboxylesterase 1 (CES1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carboxylesterase 1 (CES1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC374Ra01 Recombinant Carboxylesterase 1 (CES1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC374Ra01 Polyclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC
MAC374Ra21 Monoclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IP.
Assay Kits SEC374Ra ELISA Kit for Carboxylesterase 1 (CES1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
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  13. "Purification and characterization of retinyl ester hydrolase as a member of the non-specific carboxylesterase supergene family."Eur. J. Biochem. 251:863-873(1998) [PubMed] [Europe PMC] [Abstract]
  14. "Molecular aspects of carboxylesterase isoforms in comparison with other esterases."Toxicol. Lett. 82:439-445(1995) [PubMed] [Europe PMC] [Abstract]
  15. "Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site."Biochemistry 41:6679-6687(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Cloning and sequencing of a human liver carboxylesterase isoenzyme."Life Sci. 48:PL43-PL49(1991) [PubMed] [Europe PMC] [Abstract]
  17. "cDNA cloning and characterization of human monocyte/macrophage serine esterase-1."Blood 78:506-512(1991) [PubMed] [Europe PMC] [Abstract]
  18. "Cloning and analysis of a cDNA encoding a human liver carboxylesterase."Gene 108:289-292(1991) [PubMed] [Europe PMC] [Abstract]
  19. "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin."J. Biol. Chem. 272:14769-14775(1997) [PubMed] [Europe PMC] [Abstract]
  20. "Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis."Am. J. Hum. Genet. 82:1241-1248(2008) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine. From binding promiscuity to selective inhibition."Chem. Biol. 10:341-349(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme."Nat. Struct. Biol. 10:349-356(2003) [PubMed] [Europe PMC] [Abstract]