Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2)

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ATX; ATX-X; LysoPLD; NPP2; PD-IALPHA; PDNP2; Autotaxin; Extracellular lysophospholipase D

Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2)
Autotaxinis a secreted enzyme important for generating the lipid signaling molecule lysophosphatidic acid (LPA). Autotaxin has lysophospholipase D activity that converts lysophosphatidylcholine into LPA. Autotaxin was originally identified as a tumor cell-motility-stimulating factor; later it was shown to be LPA (which signals through Lysophospholipid receptors), the lipid product of the reaction catalyzed by autotaxin, which is responsible for its effects on cell-proliferation.
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and as a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC323Hu01 Recombinant Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC323Hu01 Polyclonal Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) WB; IHC; ICC; IP.
MAC323Hu22 Monoclonal Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) WB; IHC; ICC; IP.
MAC323Hu21 Monoclonal Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) WB
Assay Kits SEC323Hu ELISA Kit for Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) Polyclonal Antibody Customized Service Offer
Assay Kits SEC323Mu ELISA Kit for Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC323Ra01 Recombinant Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC323Ra01 Polyclonal Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) WB; IHC; ICC; IP.
MAC323Ra21 Monoclonal Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) WB; IHC; ICC; IP.
MAC323Ra23 Monoclonal Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) WB; IHC; ICC; IP.
Assay Kits SEC323Ra ELISA Kit for Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases."J. Biol. Chem. 269:30479-30484(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2)."Genomics 30:380-384(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells."Biochem. Biophys. Res. Commun. 218:714-719(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate."J. Biol. Chem. 280:21155-21161(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."J. Biol. Chem. 283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase."J. Biol. Chem. 277:39436-39442(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein."J. Biol. Chem. 267:2524-2529(1992) [PubMed] [Europe PMC] [Abstract]
  10. "Autotaxin (NPP-2), a metastasis-enhancing mitogen, is an angiogenic factor."Cancer Res. 61:6938-6944(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression."Diabetologia 48:569-577(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Structural basis of substrate discrimination and integrin binding by autotaxin." Nat. Struct. Mol. Biol. 18:198-204(2011) [PubMed] [Europe PMC] [Abstract]