Contactin Associated Protein Like Protein 2 (CNTNAP2)

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NRXN4; CASPR2; CDFE; Cell recognition molecule Caspr2

Contactin Associated Protein Like Protein 2 (CNTNAP2)

Contactin-associated protein-like 2 is a  member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons and associated with potassium channels. It may play a role in the local differentiation of the axon into distinct functional subdomains. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It may represent a positional candidate gene for the DFNB13 form of nonsyndromic deafness.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC293Hu01 Recombinant Contactin Associated Protein Like Protein 2 (CNTNAP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC293Hu01 Polyclonal Antibody to Contactin Associated Protein Like Protein 2 (CNTNAP2) WB; IHC; ICC; IP.
MAC293Hu21 Monoclonal Antibody to Contactin Associated Protein Like Protein 2 (CNTNAP2) WB; IHC; ICC; IP.
Assay Kits SEC293Hu ELISA Kit for Contactin Associated Protein Like Protein 2 (CNTNAP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Contactin Associated Protein Like Protein 2 (CNTNAP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Contactin Associated Protein Like Protein 2 (CNTNAP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Contactin Associated Protein Like Protein 2 (CNTNAP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Contactin Associated Protein Like Protein 2 (CNTNAP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Contactin Associated Protein Like Protein 2 (CNTNAP2) ELISA Kit Customized Service Offer
  1. "Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels."Neuron 24:1037-1047(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The human contactin-associated protein-like 2 gene (CNTNAP2) spans over 2 Mb of DNA at chromosome 7q35."Genomics 73:108-112(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2."N. Engl. J. Med. 354:1370-1377(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders."Am. J. Hum. Genet. 82:165-173(2008) [PubMed] [Europe PMC] [Abstract]