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Menin (MEAI)

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MEN1; SCG2; Multiple Endocrine Neoplasia I

Menin (MEAI)
CCC C248
HGNC 7010
MGI 1316736
PubMed 20833329
RGD 3078
UniProt O00255
Wiki MEN1

MEN1 is a putative tumor suppressor associated with multiple endocrine neoplasia type 1. In vitro studies have shown that menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Two variants of the shorter transcript have been identified where alternative splicing affects the coding sequence. Five variants where alternative splicing takes place in the 5' UTR have also been identified.Prognosis in MEN1 patients is related to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease, primary hyperparathyroidism, and acute forms of hyperinsulinemia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC248Hu01 Recombinant Menin (MEAI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC248Hu01 Polyclonal Antibody to Menin (MEAI) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Menin (MEAI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Menin (MEAI) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Menin (MEAI) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Menin (MEAI) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Menin (MEAI) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Menin (MEAI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Menin (MEAI) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Menin (MEAI) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Menin (MEAI) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Menin (MEAI) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Menin (MEAI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Menin (MEAI) ELISA Kit Customized Service Offer
  1. "Positional cloning of the gene for multiple endocrine neoplasia-type 1." Science 276:404-407(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Novel MEN1 germline mutations in Brazilian families with multiple endocrine neoplasia type 1."Clin. Endocrinol. (Oxf.) 67:377-384(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription."Cell 96:143-152(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation."Oncogene 20:4917-4925(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling."Proc. Natl. Acad. Sci. U.S.A. 98:3837-3842(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Menin associates with FANCD2, a protein involved in repair of DNA damage."Cancer Res. 63:4204-4210(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Multiple tumor suppressor pathways negatively regulate telomerase."Cell 113:881-889(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Functional interaction between tumor suppressor menin and activator of S-phase kinase."Cancer Res. 64:6791-6796(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus."Mol. Cell 13:587-597(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression."Mol. Cell. Biol. 24:5639-5649(2004) [PubMed] [Europe PMC] [Abstract]
  13. "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."J. Biol. Chem. 282:20395-20406(2007) [PubMed] [Europe PMC] [Abstract]
  14. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states."Hum. Mol. Genet. 6:1169-1175(1997) [PubMed] [Europe PMC] [Abstract]
  19. "Identification of the multiple endocrine neoplasia type 1 (MEN1) gene." Hum. Mol. Genet. 6:1177-1183(1997) [PubMed] [Europe PMC] [Abstract]
  20. "Somatic mutation of the MEN1 gene in parathyroid tumours." Nat. Genet. 16:375-378(1997) [PubMed] [Europe PMC] [Abstract]
  21. "Characterization of mutations in patients with multiple endocrine neoplasia type 1."Am. J. Hum. Genet. 62:232-244(1998) [PubMed] [Europe PMC] [Abstract]
  22. "Germ-line mutation analysis in patients with multiple endocrine neoplasia type 1 and related disorders." Am. J. Hum. Genet. 63:455-467(1998) [PubMed] [Europe PMC] [Abstract]
  23. "A family with isolated hyperparathyroidism segregating a missense MEN1 mutation and showing loss of the wild-type alleles in the parathyroid tumors."Am. J. Hum. Genet. 63:1544-1549(1998) [PubMed] [Europe PMC] [Abstract]
  24. "Novel V184E MEN1 germline mutation in a Japanese kindred with familial hyperparathyroidism."Am. J. Med. Genet. 80:221-222(1998) [PubMed] [Europe PMC] [Abstract]
  25. "MEN1 gene mutations in 12 MEN1 families and their associated tumors."Eur. J. Endocrinol. 139:416-420(1998) [PubMed] [Europe PMC] [Abstract]
  26. "Analysis of recurrent germline mutations in the MEN1 gene encountered in apparently unrelated families."Hum. Mutat. 12:75-82(1998) [PubMed] [Europe PMC] [Abstract]
  27. "Five novel mutations in the familial multiple endocrine neoplasia type 1 (MEN1) gene."Hum. Mutat. 12:219-219(1998) [PubMed] [Europe PMC] [Abstract]
  28. "Absence of germ-line mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in familial pituitary adenoma in contrast to MEN1 in Japanese."J. Clin. Endocrinol. Metab. 83:960-965(1998) [PubMed] [Europe PMC] [Abstract]
  29. "Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism." J. Clin. Endocrinol. Metab. 83:2621-2626(1998) [PubMed] [Europe PMC] [Abstract]
  30. "Parathyroid MEN1 gene mutations in relation to clinical characteristics of nonfamilial primary hyperparathyroidism."J. Clin. Endocrinol. Metab. 83:2960-2963(1998) [PubMed] [Europe PMC] [Abstract]
  31. "Menin mutations in MEN1 patients."J. Clin. Endocrinol. Metab. 83:3004-3005(1998) [PubMed] [Europe PMC] [Abstract]
  32. "Somatic mutations of the MEN1 tumor suppressor gene detected in sporadic angiofibromas."J. Invest. Dermatol. 111:539-540(1998) [PubMed] [Europe PMC] [Abstract]
  33. "Novel MEN1 gene mutations in familial multiple endocrine neoplasia type 1."J. Hum. Genet. 43:199-201(1998) [PubMed] [Europe PMC] [Abstract]
  34. "Identification of five novel germline mutations of the MEN1 gene in Japanese multiple endocrine neoplasia type 1 (MEN1) families."J. Med. Genet. 35:915-919(1998) [PubMed] [Europe PMC] [Abstract]
  35. "Molecular pathology of multiple endocrine neoplasia type I: two novel germline mutations and updated classification of mutations affecting MEN1 gene."Diagn. Mol. Pathol. 8:195-204(1999) [PubMed] [Europe PMC] [Abstract]
  36. "A new mutation of the MEN1 gene in an Italian kindred with multiple endocrine neoplasia type 1."Eur. J. Endocrinol. 140:429-433(1999) [PubMed] [Europe PMC] [Abstract]
  37. "Germline MEN1 mutations in sixteen Japanese families with multiple endocrine neoplasia type 1 (MEN1)."Eur. J. Endocrinol. 141:475-480(1999) [PubMed] [Europe PMC] [Abstract]
  38. "MEN I gene mutations in sporadic adrenal adenomas."Hum. Genet. 105:603-610(1999) [PubMed] [Europe PMC] [Abstract]
  39. "Mutation analysis of the MEN1 gene in Belgian patients with multiple endocrine neoplasia type 1 and related diseases."Hum. Mutat. 13:54-60(1999) [PubMed] [Europe PMC] [Abstract]
  40. "Germline mutations in the multiple endocrine neoplasia type 1 gene: evidence for frequent splicing defects."Hum. Mutat. 13:175-185(1999) [PubMed] [Europe PMC] [Abstract]
  41. "Germline mutations in the MEN1 gene: creation of a new splice acceptor site and insertion of 7 intron nucleotides into the mRNA."Int. J. Mol. Med. 4:483-485(1999) [PubMed] [Europe PMC] [Abstract]
  42. "Identification of MEN1 gene mutations in families with MEN 1 and related disorders."Br. J. Cancer 83:1009-1014(2000) [PubMed] [Europe PMC] [Abstract]
  43. "Screening of the MEN1 gene and discovery of germ-line and somatic mutations in apparently sporadic parathyroid tumors."Cancer Res. 60:5553-5557(2000) [PubMed] [Europe PMC] [Abstract]
  44. "Criteria for mutation analysis in MEN 1-suspected patients: MEN 1 case-finding."Eur. J. Clin. Invest. 30:487-492(2000) [PubMed] [Europe PMC] [Abstract]
  45. "MEN1 gene mutation analysis in Italian patients with multiple endocrine neoplasia type 1."Eur. J. Endocrinol. 142:131-137(2000) [PubMed] [Europe PMC] [Abstract]
  46. "A novel mutation of the MEN1 gene in a Japanese kindred with familial isolated primary hyperparathyroidism."Eur. J. Endocrinol. 142:138-143(2000) [PubMed] [Europe PMC] [Abstract]
  47. "A novel mutation E179K of the MEN1 gene predisposes for multiple endocrine neoplasia-type 1 (MEN1)."Hum. Mutat. 16:533-533(2000) [PubMed] [Europe PMC] [Abstract]
  48. "Familial isolated hyperparathyroidism as a variant of multiple endocrine neoplasia type 1 in a large Danish pedigree."J. Clin. Endocrinol. Metab. 85:165-167(2000) [PubMed] [Europe PMC] [Abstract]
  49. "Pituitary macroadenoma in a 5-year-old: an early expression of multiple endocrine neoplasia type 1."J. Clin. Endocrinol. Metab. 85:4776-4780(2000) [PubMed] [Europe PMC] [Abstract]
  50. "Identification of three novel menin mutations (c.741delGTCA, c.1348T>C, c.1785delA) in unrelated Italian families affected with multiple endocrine neoplasia type 1: additional information for mutational screening."Hum. Mutat. 17:237-237(2001) [PubMed] [Europe PMC] [Abstract]
  51. "Germline mutation profile of MEN1 in multiple endocrine neoplasia type 1: search for correlation between phenotype and the functional domains of the MEN1 protein."Hum. Mutat. 20:35-47(2002) [PubMed] [Europe PMC] [Abstract]
  52. "A novel six-nucleotide insertion in exon 4 of the MEN1 gene, 878insCTGCAG, in three patients with familial insulinoma and primary hyperparathyroidism."Jpn. J. Clin. Oncol. 32:368-370(2002) [PubMed] [Europe PMC] [Abstract]
  53. "Frequent occurrence of an intron 4 mutation in multiple endocrine neoplasia type 1."J. Clin. Endocrinol. Metab. 87:2688-2693(2002) [PubMed] [Europe PMC] [Abstract]
  54. "Genetic screening for MEN1 mutations in families presenting with familial primary hyperparathyroidism."World J. Surg. 26:907-913(2002) [PubMed] [Europe PMC] [Abstract]
  55. "Multiple endocrine neoplasia type 1 (MEN1) germline mutations in familial isolated primary hyperparathyroidism."Clin. Endocrinol. (Oxf.) 58:639-646(2003) [PubMed] [Europe PMC] [Abstract]
  56. "Germline mutations of the MEN1 gene in Korean families with multiple endocrine neoplasia type 1 (MEN1) or MEN1-related disorders."Clin. Genet. 64:48-53(2003) [PubMed] [Europe PMC] [Abstract]
  57. "Efficient mutation detection in MEN1 gene using a combination of single-strand conformation polymorphism (MDGA) and heteroduplex analysis."Electrophoresis 24:26-33(2003) [PubMed] [Europe PMC] [Abstract]
  58. "A novel missense mutation of the MEN1 gene in a multiple endocrine neoplasia type 1 patient associated with carcinoid syndrome."Intern. Med. 42:1112-1116(2003) [PubMed] [Europe PMC] [Abstract]
  59. "Mutational and gross deletion study of the MEN1 gene and correlation with clinical features in Spanish patients."J. Med. Genet. 40:E72-E72(2003) [PubMed] [Europe PMC] [Abstract]
  60. "Unusual presentation of multiple endocrine neoplasia type 1 in a young woman with a novel mutation of the MEN1 gene."J. Hum. Genet. 49:380-386(2004) [PubMed] [Europe PMC] [Abstract]
  61. "Novel mutations in the MEN1 gene in subjects with multiple endocrine neoplasia-1."Clin. Endocrinol. (Oxf.) 62:336-342(2005) [PubMed] [Europe PMC] [Abstract]
  62. "Clinical testing for multiple endocrine neoplasia type 1 in a DNA diagnostic laboratory."Genet. Med. 7:131-138(2005) [PubMed] [Europe PMC] [Abstract]
  63. "Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroid carcinomas."Clin. Endocrinol. (Oxf.) 67:370-376(2007) [PubMed] [Europe PMC] [Abstract]
  64. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  65. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]