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Telomerase Reverse Transcriptase (TERT)

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EST2; TCS1; TP2; TRT; hEST2; Telomerase catalytic subunit; Telomerase-associated protein 2

Telomerase Reverse Transcriptase (TERT)
CCC C241
HGNC 11730
MGI 1202709
PubMed 16756500
RGD 70494
UniProt O14746
Wiki TERT

Telomerase reverse transcriptase is a catalytic subunit of the enzyme telomerase. Its absence (usually as a result of a chromosomal mutation) is associated with the disorder Cri du chat.Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG.

The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC241Hu01 Recombinant Telomerase Reverse Transcriptase (TERT) Positive Control; Immunogen; SDS-PAGE; WB.
APC241Hu01 Active Telomerase Reverse Transcriptase (TERT) Cell culture; Activity Assays.
RPC241Hu02 Recombinant Telomerase Reverse Transcriptase (TERT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC241Hu01 Polyclonal Antibody to Telomerase Reverse Transcriptase (TERT) WB; IHC; ICC; IP.
MAC241Hu22 Monoclonal Antibody to Telomerase Reverse Transcriptase (TERT) WB; IHC; ICC; IP.
Assay Kits SEC241Hu ELISA Kit for Telomerase Reverse Transcriptase (TERT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC241Mu01 Recombinant Telomerase Reverse Transcriptase (TERT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC241Mu01 Polyclonal Antibody to Telomerase Reverse Transcriptase (TERT) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Telomerase Reverse Transcriptase (TERT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Telomerase Reverse Transcriptase (TERT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC241Ra01 Recombinant Telomerase Reverse Transcriptase (TERT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC241Ra01 Polyclonal Antibody to Telomerase Reverse Transcriptase (TERT) WB; IHC; ICC; IP.
MAC241Ra21 Monoclonal Antibody to Telomerase Reverse Transcriptase (TERT) WB; IHC; ICC; IP.
Assay Kits SEC241Ra ELISA Kit for Telomerase Reverse Transcriptase (TERT) Enzyme-linked immunosorbent assay for Antigen Detection.
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  24. "The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity."Nucleic Acids Res. 35:1155-1168(2007) [PubMed] [Europe PMC] [Abstract]
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  32. "Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation."J. Biol. Chem. 288:7252-7262(2013) [PubMed] [Europe PMC] [Abstract]
  33. "HIV-1 Vpr protein inhibits telomerase activity via the EDD-DDB1-VPRBP E3 ligase complex."J. Biol. Chem. 288:15474-15480(2013) [PubMed] [Europe PMC] [Abstract]
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