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Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1)

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NAE1; HPP1; Ula-1; NEDD8-Activating Enzyme E1 Regulatory Subunit 1; Amyloid protein-binding protein 1; Proto-oncogene protein 1

Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1)
CCC C219
HGNC 621
MGI 2384561
PubMed 14690597
RGD 619945
UniProt Q13564
Wiki APPBP1
NEDD8-activating enzyme E1 regulatory subunit binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
The APPBP1 protein is 39% identical to the protein encoded by the Arabidopsis auxin resistance gene AXR1; both proteins are relatives of ubiquitin-activating enzyme-1 (UBE1).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC219Hu01 Recombinant Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC219Hu01 Polyclonal Antibody to Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) ELISA Kit Customized Service Offer
  1. "APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein."J. Biol. Chem. 271:11339-11346(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway."J. Biol. Chem. 274:12036-12042(1999) [PubMed] [Europe PMC] [Abstract]
  8. "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons."J. Biol. Chem. 275:8929-8935(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer."J. Biol. Chem. 278:26823-26830(2003) [PubMed] [Europe PMC] [Abstract]
  10. "APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain."J. Cell Biol. 163:27-33(2003) [PubMed] [Europe PMC] [Abstract]
  11. "ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis."J. Neurochem. 85:801-809(2003) [PubMed] [Europe PMC] [Abstract]
  12. "TRIP12 functions as an E3 ubiquitin ligase of APP-BP1."Biochem. Biophys. Res. Commun. 374:294-298(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1."Mol. Cell 12:1427-1437(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8."Nature 422:330-334(2003) [PubMed] [Europe PMC] [Abstract]
  18. "A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8."Nat. Struct. Mol. Biol. 11:927-935(2004) [PubMed] [Europe PMC] [Abstract]