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Collagen Type VI Alpha 1 (COL6a1)

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COL6-A1; OPLL; Collagen Alpha-1(VI)chain

Collagen Type VI Alpha 1 (COL6a1)
CCC C150
HGNC 2211
MGI 88459
PubMed 22012643
RGD 1565398
UniProt P12109
Wiki COL6A1

The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively.

The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy.Defects in COL6A1 are a cause of Bethlem myopathy (BM).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC150Hu01 Recombinant Collagen Type VI Alpha 1 (COL6a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC150Hu01 Polyclonal Antibody to Collagen Type VI Alpha 1 (COL6a1) WB; IHC; ICC; IP.
MAC150Hu22 Monoclonal Antibody to Collagen Type VI Alpha 1 (COL6a1) WB; IHC; ICC; IP.
LAC150Hu71 Biotin-Linked Polyclonal Antibody to Collagen Type VI Alpha 1 (COL6a1) WB; IHC; ICC.
Assay Kits SEC150Hu ELISA Kit for Collagen Type VI Alpha 1 (COL6a1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC150Mu01 Recombinant Collagen Type VI Alpha 1 (COL6a1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC150Mu02 Recombinant Collagen Type VI Alpha 1 (COL6a1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC150Mu03 Recombinant Collagen Type VI Alpha 1 (COL6a1) Positive Control; Immunogen; SDS-PAGE; WB.
APC150Mu02 Active Collagen Type VI Alpha 1 (COL6a1) Cell culture; Activity Assays.
APC150Mu03 Active Collagen Type VI Alpha 1 (COL6a1) Cell culture; Activity Assays.
Antibodies PAC150Mu01 Polyclonal Antibody to Collagen Type VI Alpha 1 (COL6a1) WB; IHC; ICC; IP.
PAC150Mu03 Polyclonal Antibody to Collagen Type VI Alpha 1 (COL6a1) WB; IHC; ICC; IP.
PAC150Mu02 Polyclonal Antibody to Collagen Type VI Alpha 1 (COL6a1) WB; IHC; ICC; IP.
LAC150Mu71 Biotin-Linked Polyclonal Antibody to Collagen Type VI Alpha 1 (COL6a1) WB; IHC; ICC.
Assay Kits SEC150Mu ELISA Kit for Collagen Type VI Alpha 1 (COL6a1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC150Ra01 Recombinant Collagen Type VI Alpha 1 (COL6a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC150Ra01 Polyclonal Antibody to Collagen Type VI Alpha 1 (COL6a1) WB; IHC; ICC; IP.
MAC150Ra21 Monoclonal Antibody to Collagen Type VI Alpha 1 (COL6a1) WB; IHC; ICC; IP.
Assay Kits SEC150Ra ELISA Kit for Collagen Type VI Alpha 1 (COL6a1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Sequence analysis of alpha 1(VI) and alpha 2(VI) chains of human type VI collagen reveals internal triplication of globular domains similar to the A domains of von Willebrand factor and two alpha 2(VI) chain variants that differ in the carboxy terminus."EMBO J. 8:1939-1946(1989) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Recombinant expression and structural and binding properties of alpha 1(VI) and alpha 2(VI) chains of human collagen type VI."Eur. J. Biochem. 221:177-185(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Human COL6A1: genomic characterization of the globular domains, structural and evolutionary comparison with COL6A2."Mamm. Genome 8:342-345(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Further characterization of the three polypeptide chains of bovine and human short-chain collagen (intima collagen)."Eur. J. Biochem. 133:39-46(1983) [PubMed] [Europe PMC] [Abstract]
  6. "Amino acid sequence of the triple-helical domain of human collagen type VI."J. Biol. Chem. 263:18601-18606(1988) [PubMed] [Europe PMC] [Abstract]
  7. "The exon organization of the triple-helical coding regions of the human alpha 1(VI) and alpha 2(VI) collagen genes is highly similar."Genomics 11:145-153(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of three constituent chains of collagen type VI by peptide sequences and cDNA clones."Eur. J. Biochem. 168:309-317(1987) [PubMed] [Europe PMC] [Abstract]
  9. "Cloning and chromosomal localization of human genes encoding the three chains of type VI collagen."Am. J. Hum. Genet. 42:435-445(1988) [PubMed] [Europe PMC] [Abstract]