≡

Collagen Type XXV (COL25)

[Edit]

AMY; COL25A1; CLAC; CLAC-P; Collagen Alpha-1(XXV)Chain; Alzheimer disease amyloid-associated protein; Collagen-like Alzheimer amyloid plaque component

Collagen Type XXV (COL25)
CCC C132
HGNC 18603
MGI 1924268
PubMed 22297151
UniProt Q9BXS0
Wiki COL25A1

Collagen alpha-1(XXV) chain is is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease brains .Northern blot analysis of mouse tissues detected a 4.4-kb Col25a1 transcript in brain only, but RT-PCR showed weak expression in heart, testis, and eye as well. In situ hybridization of mouse brain revealed Col25a1 in neurons of cerebral neocortices, hippocampus, and other subcortical nuclei. SDS-PAGE of transfected human embryonic kidney cells detected COL25A1 monomers of 80 kD under reducing conditions and multimers of 160 and 240 kD under nonreducing conditions, suggesting that COL25A1 assumes a triple-helix configuration.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collagen Type XXV (COL25) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collagen Type XXV (COL25) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collagen Type XXV (COL25) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collagen Type XXV (COL25) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type XXV (COL25) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collagen Type XXV (COL25) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collagen Type XXV (COL25) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collagen Type XXV (COL25) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collagen Type XXV (COL25) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type XXV (COL25) ELISA Kit Customized Service Offer
  1. "CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV."EMBO J. 21:1524-1534(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular identification of AMY, an Alzheimer disease amyloid-associated protein."J. Neuropathol. Exp. Neurol. 62:1108-1117(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site."J. Biol. Chem. 280:1007-1015(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits."Am. J. Pathol. 165:273-281(2004) [PubMed] [Europe PMC] [Abstract]
  6. "CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation."Biochemistry 44:15602-15609(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates."FEBS J. 272:2231-2236(2005) [PubMed] [Europe PMC] [Abstract]
  8. "CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils."J. Biol. Chem. 280:8596-8605(2005) [PubMed] [Europe PMC] [Abstract]
  9. ErratumJ. Biol. Chem. 280:15484-15484(2005)
  10. "Recessive mutations in COL25A1 are a cause of congenital cranial dysinnervation disorder."Am. J. Hum. Genet. 96:147-152(2015) [PubMed] [Europe PMC] [Abstract]