Growth Differentiation Factor 11 (GDF11)

GDF11 is a protein belonging to the transforming growth factor beta superfamily that controls anterior-posterior patterning by regulating the expression of Hox genes.It determines Hox gene expression domains and rostrocaudal identity in the caudal spinal cord. During mouse development, GDF11 expression begins in the tail bud and caudal neural plate region. This cytokine also inhibits the proliferation of olfactory receptor neuron progenitors to regulate the number of olfactory receptor neurons occurring in the olfactory epithelium, and controls the competence of progenitor cells to regulate numbers of retinal ganglionic cells developing in the retina.GDF11 can bind type I TGF-beta superfamily receptors ALK4, ALK5 and ALK7), but predominantly uses ALK4 and ALK5 for signal transduction.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC113Hu01 Recombinant Growth Differentiation Factor 11 (GDF11) Positive Control; Immunogen; SDS-PAGE; WB.
RPC113Hu02 Recombinant Growth Differentiation Factor 11 (GDF11) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC113Hu01 Polyclonal Antibody to Growth Differentiation Factor 11 (GDF11) WB; IHC; ICC; IP.
MAC113Hu21 Monoclonal Antibody to Growth Differentiation Factor 11 (GDF11) WB; IHC; ICC; IP.
PAC113Hu02 Polyclonal Antibody to Growth Differentiation Factor 11 (GDF11) WB; IHC; ICC; IP.
Assay Kits SEC113Hu ELISA Kit for Growth Differentiation Factor 11 (GDF11) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC113Hu CLIA Kit for Growth Differentiation Factor 11 (GDF11) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC113Mu01 Recombinant Growth Differentiation Factor 11 (GDF11) Positive Control; Immunogen; SDS-PAGE; WB.
RPC113Mu02 Recombinant Growth Differentiation Factor 11 (GDF11) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC113Mu01 Polyclonal Antibody to Growth Differentiation Factor 11 (GDF11) WB; IHC; ICC; IP.
PAC113Mu02 Polyclonal Antibody to Growth Differentiation Factor 11 (GDF11) WB; IHC; ICC; IP.
Assay Kits SEC113Mu ELISA Kit for Growth Differentiation Factor 11 (GDF11) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC113Mu CLIA Kit for Growth Differentiation Factor 11 (GDF11) Chemiluminescent immunoassay for Antigen Detection.
HEC113Mu High Sensitive ELISA Kit for Growth Differentiation Factor 11 (GDF11) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC113Ra01 Recombinant Growth Differentiation Factor 11 (GDF11) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC113Ra01 Polyclonal Antibody to Growth Differentiation Factor 11 (GDF11) WB; IHC; ICC; IP.
MAC113Ra21 Monoclonal Antibody to Growth Differentiation Factor 11 (GDF11) WB; IHC; ICC; IP.
Assay Kits SEC113Ra ELISA Kit for Growth Differentiation Factor 11 (GDF11) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC113Ra CLIA Kit for Growth Differentiation Factor 11 (GDF11) Chemiluminescent immunoassay for Antigen Detection.
  1. "A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos."Dev. Biol. 208:222-232(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11."Nat. Genet. 22:260-264(1999) [PubMed] [Europe PMC] [Abstract]