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Growth Differentiation Factor 5 (GDF5)

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CDMP1; LAP4; SYNS2; BMP14; Radotermin; Cartilage-Derived Morphogenetic Protein-1; Bone morphogenetic protein 14; Lipopolysaccharide-associated protein 4

Growth Differentiation Factor 5 (GDF5)
CCC C110
HGNC 4220
MGI 95688
PubMed 23356643
UniProt P43026
Wiki GDF5

Growth/differentiation factor 5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues.

Growth differentiation factor 5 (GDF5) is a protein belonging to the transforming growth factor beta superfamily that is expressed in the developing central nervous system, and has a role in skeletal and joint development.It also increases the survival of neurones that respond to a neurotransmitter called dopamine, and is a potential therapeutic molecule associated with Parkinson's disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC110Hu01 Recombinant Growth Differentiation Factor 5 (GDF5) Positive Control; Immunogen; SDS-PAGE; WB.
RPC110Hu02 Recombinant Growth Differentiation Factor 5 (GDF5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC110Hu01 Polyclonal Antibody to Growth Differentiation Factor 5 (GDF5) WB; IHC; ICC; IP.
MAC110Hu22 Monoclonal Antibody to Growth Differentiation Factor 5 (GDF5) WB; IHC; ICC; IP.
LAC110Hu71 Biotin-Linked Polyclonal Antibody to Growth Differentiation Factor 5 (GDF5) WB; IHC; ICC.
LAC110Hu81 FITC-Linked Polyclonal Antibody to Growth Differentiation Factor 5 (GDF5) WB; IHC; ICC; IF.
PAC110Hu02 Polyclonal Antibody to Growth Differentiation Factor 5 (GDF5) WB; IHC; ICC; IP.
Assay Kits SEC110Hu ELISA Kit for Growth Differentiation Factor 5 (GDF5) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC110Hu CLIA Kit for Growth Differentiation Factor 5 (GDF5) Chemiluminescent immunoassay for Antigen Detection.
IEC110Hu Instant ELISA Kit for Growth Differentiation Factor 5 (GDF5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC110Mu01 Recombinant Growth Differentiation Factor 5 (GDF5) Positive Control; Immunogen; SDS-PAGE; WB.
RPC110Mu02 Recombinant Growth Differentiation Factor 5 (GDF5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC110Mu01 Polyclonal Antibody to Growth Differentiation Factor 5 (GDF5) WB; IHC; ICC; IP.
LAC110Mu71 Biotin-Linked Polyclonal Antibody to Growth Differentiation Factor 5 (GDF5) WB; IHC; ICC.
PAC110Mu02 Polyclonal Antibody to Growth Differentiation Factor 5 (GDF5) WB; IHC; ICC; IP.
Assay Kits SEC110Mu ELISA Kit for Growth Differentiation Factor 5 (GDF5) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC110Mu CLIA Kit for Growth Differentiation Factor 5 (GDF5) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC110Ra01 Recombinant Growth Differentiation Factor 5 (GDF5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC110Ra01 Polyclonal Antibody to Growth Differentiation Factor 5 (GDF5) WB; IHC; ICC; IP.
MAC110Ra21 Monoclonal Antibody to Growth Differentiation Factor 5 (GDF5) WB; IHC; ICC; IP.
Assay Kits SEC110Ra ELISA Kit for Growth Differentiation Factor 5 (GDF5) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC110Ra CLIA Kit for Growth Differentiation Factor 5 (GDF5) Chemiluminescent immunoassay for Antigen Detection.
  1. "Cloning and expression of recombinant human growth/differentiation factor 5."Biochem. Biophys. Res. Commun. 204:646-652(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development."J. Biol. Chem. 269:28227-28234(1994) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A CD14-independent LPS receptor cluster."Nat. Immunol. 2:338-345(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Cartilage-derived morphogenetic protein-1 promotes the differentiation of mesenchymal stem cells into chondrocytes."Biochem. Biophys. Res. Commun. 325:453-460(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN."PLoS Genet. 5:E1000747-E1000747(2009) [PubMed] [Europe PMC] [Abstract]
  8. "New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance."J. Bone Miner. Res. 27:429-442(2012) [PubMed] [Europe PMC] [Abstract]
  9. "A GDF5 point mutation strikes twice--causing BDA1 and SYNS2."PLoS Genet. 9:E1003846-E1003846(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular analysis of two novel missense mutations in the GDF5 proregion that reduce protein activity and are associated with brachydactyly type C."J. Mol. Biol. 426:3221-3231(2014) [PubMed] [Europe PMC] [Abstract]
  11. "A novel mutation in CDMP1 causes brachydactyly type C with 'angel-shaped phalanx'. A genotype-phenotype correlation in the mutational spectrum."Eur. J. Med. Genet. 55:611-614(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity."EMBO J. 28:937-947(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1."Nat. Genet. 17:58-64(1997) [PubMed] [Europe PMC] [Abstract]
  14. "Multiple synostosis type 2 (SYNS2) maps to 20q11.2 and caused by a missense mutation in the growth/differentiation factor 5 (GDF5)."Am. J. Hum. Genet. 65:A281-A281(1999)
  15. "Mutation in the cartilage-derived morphogenetic protein-1 (CDMP1) gene in a kindred affected with fibular hypoplasia and complex brachydactyly (DuPan syndrome)."Clin. Genet. 61:454-458(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Brachydactyly type C caused by a homozygous missense mutation in the prodomain of CDMP1."Am. J. Med. Genet. A 124:356-363(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Du Pan syndrome phenotype caused by heterozygous pathogenic mutations in CDMP1 gene."Am. J. Med. Genet. A 138:379-383(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2."J. Clin. Invest. 115:2373-2381(2005) [PubMed] [Europe PMC] [Abstract]
  19. "GDF5 is a second locus for multiple-synostosis syndrome."Am. J. Hum. Genet. 78:708-712(2006) [PubMed] [Europe PMC] [Abstract]
  20. "A novel mutation in GDF5 causes autosomal dominant symphalangism in two Chinese families."Am. J. Med. Genet. A 140:1846-1853(2006) [PubMed] [Europe PMC] [Abstract]
  21. "A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis."Nat. Genet. 39:529-533(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Compound heterozygosity for GDF5 in Du Pan type chondrodysplasia."Am. J. Med. Genet. A 146:2116-2121(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Brachydactyly type A2 associated with a defect in proGDF5 processing."Hum. Mol. Genet. 17:1222-1233(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Novel point mutations in GDF5 associated with two distinct limb malformations in Chinese: brachydactyly type C and proximal symphalangism."J. Hum. Genet. 53:368-374(2008) [PubMed] [Europe PMC] [Abstract]
  25. "Mutations in GDF5 presenting as semidominant brachydactyly A1."Hum. Mutat. 31:1155-1162(2010) [PubMed] [Europe PMC] [Abstract]