Interleukin 24 (IL24)
[Edit]C49A; FISP; IL10B; MDA7; Mob-5; ST16; Mda-7; Melanoma Differentiation Association Protein 7; Suppression Of Tumorigenicity 16
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Interleukin 24 (IL-24) is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as Melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called Stat-1 and Stat-3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 cells and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer. Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC064Hu01 | Recombinant Interleukin 24 (IL24) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APC064Hu01 | Active Interleukin 24 (IL24) | Cell culture; Activity Assays. | |
| Antibodies | PAC064Hu01 | Polyclonal Antibody to Interleukin 24 (IL24) | WB; IHC |
| MAC064Hu22 | Monoclonal Antibody to Interleukin 24 (IL24) | WB; IHC; ICC; IP. | |
| LAC064Hu71 | Biotin-Linked Polyclonal Antibody to Interleukin 24 (IL24) | WB; IHC; ICC. | |
| Assay Kits | SEC064Hu | ELISA Kit for Interleukin 24 (IL24) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC064Hu | CLIA Kit for Interleukin 24 (IL24) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC064Mu01 | Recombinant Interleukin 24 (IL24) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC064Mu02 | Recombinant Interleukin 24 (IL24) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC064Mu01 | Polyclonal Antibody to Interleukin 24 (IL24) | WB; IHC; ICC; IP. |
| PAC064Mu02 | Polyclonal Antibody to Interleukin 24 (IL24) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC064Mu | ELISA Kit for Interleukin 24 (IL24) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC064Mu | CLIA Kit for Interleukin 24 (IL24) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC064Ra01 | Recombinant Interleukin 24 (IL24) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC064Ra01 | Polyclonal Antibody to Interleukin 24 (IL24) | WB; IHC; ICC; IP. |
| LAC064Ra71 | Biotin-Linked Polyclonal Antibody to Interleukin 24 (IL24) | WB; IHC; ICC. | |
| MAC064Ra21 | Monoclonal Antibody to Interleukin 24 (IL24) | WB; IHC; ICC; IP. | |
| MAC064Ra22 | Monoclonal Antibody to Interleukin 24 (IL24) | WB; IHC; ICC; IP. | |
| MAC064Ra23 | Monoclonal Antibody to Interleukin 24 (IL24) | WB; IHC; ICC; IP. | |
| MAC064Ra24 | Monoclonal Antibody to Interleukin 24 (IL24) | WB; IHC; ICC; IP. | |
| MAC064Ra25 | Monoclonal Antibody to Interleukin 24 (IL24) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC064Ra | ELISA Kit for Interleukin 24 (IL24) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC064Ra | CLIA Kit for Interleukin 24 (IL24) | Chemiluminescent immunoassay for Antigen Detection. |
- "Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression."Oncogene 11:2477-2486(1995) [PubMed] [Europe PMC] [Abstract]
- "Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties." Oncogene 20:7051-7063(2001) [PubMed] [Europe PMC] [Abstract]
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- "Critical role of lysine 123 in the ubiquitin-mediated degradation of MDA-7/IL-24."J. Interferon Cytokine Res. 32:575-582(2012) [PubMed] [Europe PMC] [Abstract]