Interleukin 4 Receptor (IL4R)

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CD124; IL4-R; IL4RA; IL4-BP; Soluble interleukin-4 receptor subunit alpha; IL-4-binding protein

Interleukin 4 Receptor (IL4R)

Interleukin 4 receptor is the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells.

Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC031Hu01 Recombinant Interleukin 4 Receptor (IL4R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC031Hu01 Polyclonal Antibody to Interleukin 4 Receptor (IL4R) WB; IHC; ICC; IP.
MAC031Hu22 Monoclonal Antibody to Interleukin 4 Receptor (IL4R) WB; IHC; ICC; IP.
Assay Kits SEC031Hu ELISA Kit for Interleukin 4 Receptor (IL4R) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC031Mu01 Recombinant Interleukin 4 Receptor (IL4R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC031Mu01 Polyclonal Antibody to Interleukin 4 Receptor (IL4R) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interleukin 4 Receptor (IL4R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 4 Receptor (IL4R) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC031Ra01 Recombinant Interleukin 4 Receptor (IL4R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC031Ra01 Polyclonal Antibody to Interleukin 4 Receptor (IL4R) WB; IHC; ICC; IP.
LAC031Ra71 Biotin-Linked Polyclonal Antibody to Interleukin 4 Receptor (IL4R) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Interleukin 4 Receptor (IL4R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 4 Receptor (IL4R) ELISA Kit Customized Service Offer
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  12. "JAK3 associates with the human interleukin 4 receptor and is tyrosine phosphorylated following receptor triggering."Oncogene 10:1757-1761(1995) [PubMed] [Europe PMC] [Abstract]
  13. "IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells."FEBS Lett. 393:53-56(1996) [PubMed] [Europe PMC] [Abstract]
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  15. "Soluble human interleukin-4 receptor is produced by activated T cells under the control of metalloproteinases."Int. Arch. Allergy Immunol. 119:23-30(1999) [PubMed] [Europe PMC] [Abstract]
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  20. "Common polymorphisms in the coding part of the IL4-receptor gene."Biochem. Biophys. Res. Commun. 231:696-697(1997) [PubMed] [Europe PMC] [Abstract]
  21. "The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor."N. Engl. J. Med. 337:1720-1725(1997) [PubMed] [Europe PMC] [Abstract]
  22. "Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma."Nat. Genet. 19:119-120(1998) [PubMed] [Europe PMC] [Abstract]
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  24. "The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction."Immunology 96:365-371(1999) [PubMed] [Europe PMC] [Abstract]
  25. "Effects of an allergy-associated mutation in the human IL-4R alpha (Q576R) on human IL-4-induced signal transduction."J. Immunol. 162:4385-4389(1999) [PubMed] [Europe PMC] [Abstract]
  26. "Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations."Am. J. Hum. Genet. 66:517-526(2000) [PubMed] [Europe PMC] [Abstract]
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