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Toll Like Receptor 5 (TLR5)

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CD285; SLEB1; TIL3; Toll/Interleukin-1 Receptor-Like Protein 3

Toll Like Receptor 5 (TLR5)
CCC B990
HGNC 11851
MGI 1858171
PubMed 19774646
RGD 631351
UniProt O60602
Wiki TLR_5

Toll-like receptor 5 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene product is expressed in myelomonocytic cells, and recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha production.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB990Hu01 Recombinant Toll Like Receptor 5 (TLR5) Positive Control; Immunogen; SDS-PAGE; WB.
RPB990Hu02 Recombinant Toll Like Receptor 5 (TLR5) Positive Control; Immunogen; SDS-PAGE; WB.
RPB990Hu03 Recombinant Toll Like Receptor 5 (TLR5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB990Hu01 Polyclonal Antibody to Toll Like Receptor 5 (TLR5) WB
PAB990Hu03 Polyclonal Antibody to Toll Like Receptor 5 (TLR5) WB; ICC; IHC-P; IHC-F; ELISA.
PAB990Hu02 Polyclonal Antibody to Toll Like Receptor 5 (TLR5) WB; IHC; ICC; IP.
LAB990Hu71 Biotin-Linked Polyclonal Antibody to Toll Like Receptor 5 (TLR5) WB; IHC; ICC.
LAB990Hu81 FITC-Linked Polyclonal Antibody to Toll Like Receptor 5 (TLR5) WB; IHC; ICC; IF.
MAB990Hu21 Monoclonal Antibody to Toll Like Receptor 5 (TLR5) WB,IHC
MAB990Hu22 Monoclonal Antibody to Toll Like Receptor 5 (TLR5) WB; IHC; ICC; IP.
LAB990Hu73 Biotin-Linked Polyclonal Antibody to Toll Like Receptor 5 (TLR5) WB; IHC; ICC.
MAB990Hu23 Monoclonal Antibody to Toll Like Receptor 5 (TLR5) WB; IHC; ICC; IP.
Assay Kits SEB990Hu ELISA Kit for Toll Like Receptor 5 (TLR5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB990Mu01 Recombinant Toll Like Receptor 5 (TLR5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB990Mu01 Polyclonal Antibody to Toll Like Receptor 5 (TLR5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Toll Like Receptor 5 (TLR5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Toll Like Receptor 5 (TLR5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB990Ra01 Recombinant Toll Like Receptor 5 (TLR5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB990Ra01 Polyclonal Antibody to Toll Like Receptor 5 (TLR5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Toll Like Receptor 5 (TLR5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Toll Like Receptor 5 (TLR5) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans."Blood 91:4020-4027(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Natural selection in the TLR-related genes in the course of primate evolution."Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
  3. "A history of recurrent positive selection at the toll-like receptor 5 in primates."Mol. Biol. Evol. 26:937-949(2009) [PubMed] [Europe PMC] [Abstract]
  4. "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A family of human receptors structurally related to Drosophila Toll."Proc. Natl. Acad. Sci. U.S.A. 95:588-593(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5."Nature 410:1099-1103(2001) [PubMed] [Europe PMC] [Abstract]
  10. "A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus."Proc. Natl. Acad. Sci. U.S.A. 102:10593-10597(2005) [PubMed] [Europe PMC] [Abstract]
  11. "A phosphorylation site in the Toll-like receptor 5 TIR domain is required for inflammatory signalling in response to flagellin."Biochem. Biophys. Res. Commun. 352:936-941(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin."J. Immunol. 178:5735-5743(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Impaired TLR5 functionality is associated with survival in melioidosis."J. Immunol. 190:3373-3379(2013) [PubMed] [Europe PMC] [Abstract]
  14. "Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin."J. Struct. Biol. 177:402-409(2012) [PubMed] [Europe PMC] [Abstract]
  15. "A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease."J. Exp. Med. 198:1563-1572(2003) [PubMed] [Europe PMC] [Abstract]