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Tenascin C (TNC)

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TN-C; HXB; TN; GMEM; JI; Myotendinous antigen; Neuronectin; GP 150-225; Cytotactin; Hexabrachion; Glioma-associated-extracellular matrix antigen

Tenascin C (TNC)
CCC B975
HGNC 5318
MGI 101922
PubMed 21281808
RGD 621057
UniProt P24821
Wiki Tenascin_C

Tenascin is an extracellular matrix protein with a spatially and temporally restricted tissue distribution. It is a hexomeric, multidomain protein with disulfide-linked subunits of 190 to 240 kD, originally characterized as 'myotendinous antigen.' In the embryo it is present in dense mesenchyme surrounding developing epithelia, in tendon anlagen, and in developing cartilage and bone. In the adult tenascin remains present in tendons and myotendinous junctions in the perichondrium and periosteum, as well as in smooth muscle. Pearson et al. (1988) isolated cDNA clones coding for tenascin from a chicken fibroblast cDNA expression library using a specific tenascin antiserum. They showed induction of tenascin in vitro by fetal calf serum as well as by transforming growth factor-beta .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB975Hu01 Recombinant Tenascin C (TNC) Positive Control; Immunogen; SDS-PAGE; WB.
RPB975Hu02 Recombinant Tenascin C (TNC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB975Hu01 Polyclonal Antibody to Tenascin C (TNC) WB; IHC; ICC; IP.
MAB975Hu22 Monoclonal Antibody to Tenascin C (TNC) WB; IHC; ICC; IP.
LAB975Hu71 Biotin-Linked Polyclonal Antibody to Tenascin C (TNC) WB; IHC; ICC.
MAB975Hu21 Monoclonal Antibody to Tenascin C (TNC) WB; IHC; ICC; IP.
MAB975Hu23 Monoclonal Antibody to Tenascin C (TNC) WB; IHC; ICC; IP.
MAB975Hu24 Monoclonal Antibody to Tenascin C (TNC) WB; IHC; ICC; IP.
PAB975Hu02 Polyclonal Antibody to Tenascin C (TNC) WB; IHC; ICC; IP.
Assay Kits SEB975Hu ELISA Kit for Tenascin C (TNC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB975Mu01 Recombinant Tenascin C (TNC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB975Mu01 Polyclonal Antibody to Tenascin C (TNC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tenascin C (TNC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tenascin C (TNC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB975Ra01 Recombinant Tenascin C (TNC) Positive Control; Immunogen; SDS-PAGE; WB.
RPB975Ra02 Recombinant Tenascin C (TNC) Positive Control; Immunogen; SDS-PAGE; WB.
RPB975Ra03 Recombinant Tenascin C (TNC) Positive Control; Immunogen; SDS-PAGE; WB.
RPB975Ra05 Recombinant Tenascin C (TNC) Positive Control; Immunogen; SDS-PAGE; WB.
RPB975Ra06 Recombinant Tenascin C (TNC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB975Ra01 Polyclonal Antibody to Tenascin C (TNC) WB,IHC
PAB975Ra02 Polyclonal Antibody to Tenascin C (TNC) WB; IHC; ICC; IP.
LAB975Ra71 Biotin-Linked Polyclonal Antibody to Tenascin C (TNC) WB; IHC; ICC.
PAB975Ra03 Polyclonal Antibody to Tenascin C (TNC) WB
Assay Kits SEB975Ra ELISA Kit for Tenascin C (TNC) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats."J. Biol. Chem. 266:2818-2823(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies."Nucleic Acids Res. 19:525-531(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Structure of the human hexabrachion (tenascin) gene."Proc. Natl. Acad. Sci. U.S.A. 88:9438-9442(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences."J. Biol. Chem. 270:3429-3434(1995) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes."Biochim. Biophys. Acta 1219:613-622(1994) [PubMed] [Europe PMC] [Abstract]
  7. "An alternatively spliced region of the human hexabrachion contains a repeat of potential N-glycosylation sites."Proc. Natl. Acad. Sci. U.S.A. 86:1588-1592(1989) [PubMed] [Europe PMC] [Abstract]
  8. "Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules."J. Biol. Chem. 271:26110-26116(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein."Science 258:987-991(1992) [PubMed] [Europe PMC] [Abstract]
  15. "Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss." PLoS ONE 8:E69549-E69549(2013) [PubMed] [Europe PMC] [Abstract]