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Tar DNA Binding Protein 43kDa (TDP43)

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TARDBP; ALS10

Tar DNA Binding Protein 43kDa (TDP43)
CCC B951
HGNC 11571
MGI 2387629
PubMed 20720505
UniProt Q13148
Wiki TARDBP

TAR DNA-binding protein is a cellular factor of 43 kDa that binds specifically to pyrimidine-rich motifs in TAR. Antibody to TDP-43 was used in gel retardation assays to demonstrate that endogenous TDP-43, present in HeLa nuclear extract, also bound to TAR DNA.

Although TDP-43 bound strongly to double-stranded TAR DNA via its ribonucleoprotein protein- binding motifs, it did not bind to TAR RNA extending from 1 to 80. TDP-43 is capable of modulating both in vitro and in vivo HIV-1 gene expression by either altering or blocking the assembly of transcription complexes that are capable of responding to Tat.TDP-43 is the major disease protein in both disorders.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB951Hu01 Recombinant Tar DNA Binding Protein 43kDa (TDP43) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB951Hu01 Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) WB; IHC; ICC; IP.
MAB951Hu22 Monoclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) WB; IHC; ICC; IP.
Assay Kits SEB951Hu ELISA Kit for Tar DNA Binding Protein 43kDa (TDP43) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB951Mu01 Recombinant Tar DNA Binding Protein 43kDa (TDP43) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB951Mu01 Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tar DNA Binding Protein 43kDa (TDP43) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit Customized Service Offer
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  2. "TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein."Mol. Cell. Neurosci. 35:320-327(2007) [PubMed] [Europe PMC] [Abstract]
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  7. , Submitted (MAR-2007) to UniProtKB
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  9. "Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping."EMBO J. 20:1774-1784(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9."J. Biol. Chem. 276:36337-36343(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS." Nature 466:1069-1075(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Mutations in the matrin 3 gene cause familial amyotrophic lateral sclerosis." Nat. Neurosci. 17:664-666(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of the RNA binding domains of TAR DNA-binding protein-43."Submitted (NOV-2005) to the PDB data bank
  17. "Solution structure of RRM domain in tar DNA-binding protein-43."Submitted (FEB-2009) to the PDB data bank
  18. "TDP-43 A315T mutation in familial motor neuron disease."Ann. Neurol. 63:535-538(2008) [PubMed] [Europe PMC] [Abstract]
  19. "TDP-43 mutation in familial amyotrophic lateral sclerosis."Ann. Neurol. 63:538-542(2008) [PubMed] [Europe PMC] [Abstract]
  20. "TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis." Lancet Neurol. 7:409-416(2008) [PubMed] [Europe PMC] [Abstract]
  21. "TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis."Nat. Genet. 40:572-574(2008) [PubMed] [Europe PMC] [Abstract]
  22. "TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis."Science 319:1668-1672(2008) [PubMed] [Europe PMC] [Abstract]
  23. "TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration."Ann. Neurol. 65:470-473(2009) [PubMed] [Europe PMC] [Abstract]
  24. "High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis."Hum. Mutat. 30:688-694(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Mutation within TARDBP leads to frontotemporal dementia without motor neuron disease."Hum. Mutat. 30:E974-E983(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Genetic variants in the promoter of TARDBP in sporadic amyotrophic lateral sclerosis."Neuromuscul. Disord. 19:696-700(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Large proportion of amyotrophic lateral sclerosis cases in Sardinia due to a single founder mutation of the TARDBP gene." Arch. Neurol. 68:594-598(2011) [PubMed] [Europe PMC] [Abstract]
  28. "High frequency of the TARDBP p.Ala382Thr mutation in Sardinian patients with amyotrophic lateral sclerosis."Clin. Genet. 81:172-178(2012) [PubMed] [Europe PMC] [Abstract]
  29. "Novel TARDBP mutations in Nordic ALS patients."J. Hum. Genet. 57:316-319(2012) [PubMed] [Europe PMC] [Abstract]