Syndecan 4 (SDC4)

Syndecan-4 is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The protein is found as a homodimer and is a member of the syndecan proteoglycan family. Syndecan4 is upregulated in osteoarthritis and inhibition of syndecan 4 reduces cartilage destruction in mouse models of OA.

Syndecans, including SDC4, can function as in trans HIV receptors via binding of HIV-1 gp120 to the syndecan heparan sulfate chains. Flow cytometric analysis demonstrated SDC expression on endothelial cells. HIV bound to SDC on endothelial cell lines maintained its infectivity for at least 1 week, compared with less than 1 day for unbound virus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB939Hu01 Recombinant Syndecan 4 (SDC4) Positive Control; Immunogen; SDS-PAGE; WB.
APB939Hu01 Active Syndecan 4 (SDC4) Cell culture; Activity Assays.
Antibodies PAB939Hu01 Polyclonal Antibody to Syndecan 4 (SDC4) WB; ICC; IHC-P; IHC-F; ELISA.
MAB939Hu22 Monoclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC; IP.
Assay Kits SEB939Hu ELISA Kit for Syndecan 4 (SDC4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB939Mu01 Recombinant Syndecan 4 (SDC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB939Mu01 Polyclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC; IP.
LAB939Mu71 Biotin-Linked Polyclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Syndecan 4 (SDC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Syndecan 4 (SDC4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB939Ra01 Recombinant Syndecan 4 (SDC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB939Ra01 Polyclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC; IP.
LAB939Ra71 Biotin-Linked Polyclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC.
LAB939Ra81 FITC-Linked Polyclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC; IF.
MAB939Ra21 Monoclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC; IP.
Assay Kits SEB939Ra ELISA Kit for Syndecan 4 (SDC4) Enzyme-linked immunosorbent assay for Antigen Detection.
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