Cathepsin S (CTSS)

CTSS is a member of the peptidase C1 family, is a lysosomal cysteine protease that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages.

Cathepsin S has been shown to be a significant prognostic factor for patients with type IV astrocytomas (glioblastoma multiforme) and its inhibition has shown improvement in survival time by mean average 5 months. This is because the cysteine enzyme can no longer act together with other proteases to break up the brain extracellular matrix. So the spread of the tumor is halted.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB933Hu01 Recombinant Cathepsin S (CTSS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB933Hu01 Polyclonal Antibody to Cathepsin S (CTSS) WB; IHC; ICC; IP.
MAB933Hu22 Monoclonal Antibody to Cathepsin S (CTSS) WB; IHC; ICC; IP.
MAB933Hu21 Monoclonal Antibody to Cathepsin S (CTSS) WB
Assay Kits SEB933Hu ELISA Kit for Cathepsin S (CTSS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB933Mu01 Recombinant Cathepsin S (CTSS) Positive Control; Immunogen; SDS-PAGE; WB.
RPB933Mu02 Recombinant Cathepsin S (CTSS) Positive Control; Immunogen; SDS-PAGE; WB.
APB933Mu01 Active Cathepsin S (CTSS) Cell culture; Activity Assays.
Antibodies PAB933Mu01 Polyclonal Antibody to Cathepsin S (CTSS) WB; IHC; ICC; IP.
LAB933Mu71 Biotin-Linked Polyclonal Antibody to Cathepsin S (CTSS) WB; IHC; ICC.
LAB933Mu81 FITC-Linked Polyclonal Antibody to Cathepsin S (CTSS) WB; IHC; ICC; IF.
PAB933Mu02 Polyclonal Antibody to Cathepsin S (CTSS) WB; IHC; ICC; IP.
Assay Kits SEB933Mu ELISA Kit for Cathepsin S (CTSS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB933Ra01 Recombinant Cathepsin S (CTSS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB933Ra01 Polyclonal Antibody to Cathepsin S (CTSS) WB; IHC; ICC; IP.
MAB933Ra21 Monoclonal Antibody to Cathepsin S (CTSS) WB; IHC; ICC; IP.
Assay Kits SEB933Ra ELISA Kit for Cathepsin S (CTSS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB933Bo01 Recombinant Cathepsin S (CTSS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB933Bo01 Polyclonal Antibody to Cathepsin S (CTSS) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cathepsin S (CTSS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cathepsin S (CTSS) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease."J. Biol. Chem. 267:7258-7262(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S."J. Biol. Chem. 267:13708-13713(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Human cathepsin S: chromosomal localization, gene structure, and tissue distribution."J. Biol. Chem. 269:11530-11536(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Three-dimensional structures of the cysteine proteases cathepsins K and S deduced by knowledge-based modelling and active site characteristics."Protein Eng. 11:1007-1013(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Structure of a Cys25-->Ser mutant of human cathepsin S."Acta Crystallogr. D 58:451-455(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode."J. Med. Chem. 50:2693-2699(2007) [PubMed] [Europe PMC] [Abstract]