Apotransferrin (apoTf)

Transferrin is a glycoprotein that binds iron very tightly but reversibly. Although iron bound to transferrin is less than 0.1% (4 mg) of the total body iron, it is the most important iron pool, with the highest rate of turnover (25 mg/24 h). Transferrin has a molecular weight of around 80 kiloDaltons and contains 2 specific high-affinity Fe(III) binding sites. The affinity of transferrin for Fe(III) is extremely high (1023 M-1 at pH 7.4 but decreases progressively with decreasing pH below neutrality.When not bound to iron, it is known as "apo-transferrin". The rate of iron release from HepG2 liver cells was increased not only by extracellular apotransferrin, but also by diferric transferrin, in a non-additive, concentration-dependent manner and to a similar magnitude. This suggests that rapid equilibration between receptor-mediated uptake and the release process determines net iron retention by the liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPB930Hu01 Native Apotransferrin (apoTf) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB930Hu01 Polyclonal Antibody to Apotransferrin (apoTf) WB; IHC; ICC; IP.
LAB930Hu71 Biotin-Linked Polyclonal Antibody to Apotransferrin (apoTf) WB; IHC; ICC.
MAB930Hu21 Monoclonal Antibody to Apotransferrin (apoTf) WB; IHC; ICC; IP.
Assay Kits SEB930Hu ELISA Kit for Apotransferrin (apoTf) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB930Hu CLIA Kit for Apotransferrin (apoTf) Chemiluminescent immunoassay for Antigen Detection.