S Antigen (SAG)

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S-AG; Retina And Pineal Gland; Arrestin; 48 kDa protein; Retinal S-antigen; Rod photoreceptor arrestin

S Antigen (SAG)

S-antigen; retina and pineal gland  is a Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB911Hu01 Recombinant S Antigen (SAG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB911Hu01 Polyclonal Antibody to S Antigen (SAG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for S Antigen (SAG) CLIA Kit Customized Service Offer
n/a ELISA Kit for S Antigen (SAG) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB911Mu01 Recombinant S Antigen (SAG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB911Mu01 Polyclonal Antibody to S Antigen (SAG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for S Antigen (SAG) CLIA Kit Customized Service Offer
n/a ELISA Kit for S Antigen (SAG) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant S Antigen (SAG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to S Antigen (SAG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to S Antigen (SAG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for S Antigen (SAG) CLIA Kit Customized Service Offer
n/a ELISA Kit for S Antigen (SAG) ELISA Kit Customized Service Offer
  1. "The sequence of human retinal S-antigen reveals similarities with alpha-transducin."FEBS Lett. 234:39-43(1988) [PubMed] [Europe PMC] [Abstract]
  2. ErratumFEBS Lett. 236:507-507(1988)
  3. "Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness."Nat. Genet. 15:175-178(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Mapping of transcription start sites of human retina expressed genes."BMC Genomics 8:42-42(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A homozygous 1-base pair deletion in the arrestin gene is a frequent cause of Oguchi disease in Japanese."Nat. Genet. 10:360-362(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Arrestin gene mutations in autosomal recessive retinitis pigmentosa."Arch. Ophthalmol. 116:498-501(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Robust self-association is a common feature of mammalian visual arrestin-1."Biochemistry 50:2235-2242(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Evaluation of the human arrestin gene in patients with retinitis pigmentosa and stationary night blindness."Invest. Ophthalmol. Vis. Sci. 39:665-670(1998) [PubMed] [Europe PMC] [Abstract]