Major Histocompatibility Complex Class I G (MHCG)

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HLA-G; MHC-G; HLAG; Leukocyte Antigen G; b2 microglobulin; HLA class I histocompatibility antigen, alpha chain G

Major Histocompatibility Complex Class I G (MHCG)

HLA-G differs from the other MHC class I genes by its low polymorphism and alternative splicing that generates seven HLA-G proteins, whose tissue-distribution is restricted to normal fetal and adult tissues that display a tolerogeneic function toward both innate and acquired immune cells. Soluble HLA-G is an immunosuppressive molecule inducing apoptosis of activated CD8 T cells and down-modulating CD4 T cell proliferation. Monitoring of sHLA-G in amniotic fluid and plasma of pregnant women may have an important prognostic value to recognize pathological situations.

In addition, soluble HLA-G plasma levels are increased in lyphoproliferative disorders or in patients suffering from malignant melanoma, glioma, breast and ovarian cancer.HLA-G belongs to the HLA nonclassical class I heavy chain paralogues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB856Hu01 Recombinant Major Histocompatibility Complex Class I G (MHCG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB856Hu01 Polyclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) WB; ICC; IHC-P; IHC-F; ELISA.
MAB856Hu22 Monoclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) WB; IHC; ICC; IP.
LAB856Hu71 Biotin-Linked Polyclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) WB; IHC; ICC.
Assay Kits SEB856Hu ELISA Kit for Major Histocompatibility Complex Class I G (MHCG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Histocompatibility Complex Class I G (MHCG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Histocompatibility Complex Class I G (MHCG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Histocompatibility Complex Class I G (MHCG) ELISA Kit Customized Service Offer
  1. "The mRNA of a human class I gene HLA G/HLA 6.0 exhibits a restricted pattern of expression."Nucleic Acids Res. 18:2189-2189(1990) [PubMed] [Europe PMC] [Abstract]
  2. "A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment."Proc. Natl. Acad. Sci. U.S.A. 84:9145-9149(1987) [PubMed] [Europe PMC] [Abstract]
  3. "A 356-Kb sequence of the subtelomeric part of the MHC class I region."DNA Seq. 10:263-299(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Disulfide bond-mediated dimerization of HLA-G on the cell surface."Proc. Natl. Acad. Sci. U.S.A. 99:16180-16185(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface."Proc. Natl. Acad. Sci. U.S.A. 102:3360-3365(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer."J. Biol. Chem. 281:10439-10447(2006) [PubMed] [Europe PMC] [Abstract]