Matrix Metalloproteinase 17 (MMP17)

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MT4-MMP; MMP4; Membrane-type matrix metalloproteinase 4; Membrane-type-4 matrix metalloproteinase

Matrix Metalloproteinase 17 (MMP17)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.

The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.In melanocytic cells MMP17 gene expression may be regulated by MITF.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB846Hu01 Recombinant Matrix Metalloproteinase 17 (MMP17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB846Hu01 Polyclonal Antibody to Matrix Metalloproteinase 17 (MMP17) WB; IHC; ICC; IP.
MAB846Hu21 Monoclonal Antibody to Matrix Metalloproteinase 17 (MMP17) WB; IHC; ICC; IP.
Assay Kits SEB846Hu ELISA Kit for Matrix Metalloproteinase 17 (MMP17) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Matrix Metalloproteinase 17 (MMP17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Matrix Metalloproteinase 17 (MMP17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Matrix Metalloproteinase 17 (MMP17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Matrix Metalloproteinase 17 (MMP17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Matrix Metalloproteinase 17 (MMP17) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Matrix Metalloproteinase 17 (MMP17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Matrix Metalloproteinase 17 (MMP17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Matrix Metalloproteinase 17 (MMP17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Matrix Metalloproteinase 17 (MMP17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Matrix Metalloproteinase 17 (MMP17) ELISA Kit Customized Service Offer
  1. "Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts."FEBS Lett. 457:353-356(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma."Cancer Res. 56:944-949(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain."J. Biol. Chem. 274:33043-33049(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase."J. Biol. Chem. 274:34260-34266(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Biochemical characterization of the catalytic domain of membrane-type 4 matrix metalloproteinase."Biol. Chem. 380:1103-1108(1999) [PubMed] [Europe PMC] [Abstract]