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Small Breast Epithelial Mucin (SBEM)

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MUCL1; Mucin-Like Protein 1; Protein BS106; Mucin-like protein 1

Small Breast Epithelial Mucin (SBEM)
CCC B840
HGNC 30588
MGI 98393
PubMed 18269587
UniProt Q96DR8
Wiki MUCL1

Small breast epithelial mucin (SBEM) is a recently described gene product that shows promise as a new breast biomarker.Using expression profiling of EST and SAGE databases, Miksicek et al. (2002) identified SBEM, which encodes a putative 90-amino acid protein. SBEM has a hydrophobic signal peptide, suggesting that it is a secreted protein subject to proteolytic processing, and it is predicted to be O-glycosylated. SBEM contains 3 tandem copies of a neutral octapeptide core repeat, and its N- and C-terminal regions are charged and fairly polar. These features are similar to many sialomucins, although the protein lacks a transmembrane domain and is shorter than most other known epithelial mucins. RNA hybridization analysis showed SBEM expression in only adult mammary and salivary glands.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB840Hu01 Recombinant Small Breast Epithelial Mucin (SBEM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB840Hu01 Polyclonal Antibody to Small Breast Epithelial Mucin (SBEM) WB; IHC; ICC; IP.
MAB840Hu22 Monoclonal Antibody to Small Breast Epithelial Mucin (SBEM) WB; IHC; ICC; IP.
Assay Kits SEB840Hu ELISA Kit for Small Breast Epithelial Mucin (SBEM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Breast Epithelial Mucin (SBEM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Breast Epithelial Mucin (SBEM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Breast Epithelial Mucin (SBEM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Breast Epithelial Mucin (SBEM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Breast Epithelial Mucin (SBEM) ELISA Kit Customized Service Offer
  1. "Identification of a novel breast- and salivary gland-specific, mucin-like gene strongly expressed in normal and tumor human mammary epithelium."Cancer Res. 62:2736-2740(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and immunohistochemical characterization of a mucin-like glycoprotein expressed in early stage breast carcinoma."Tumor Biol. 23:263-278(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Serological identification of breast cancer-related antigens from a Saccharomyces cerevisiae surface display library."Int. J. Cancer 117:104-113(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human small breast epithelial mucin: the promise of a new breast tumor biomarker."DNA Cell Biol. 23:842-849(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of MGB1 as a marker in the differential diagnosis of lung tumors in patients with a history of breast cancer by analysis of publicly available SAGE data."J. Mol. Diagn. 6:90-95(2004) [PubMed] [Europe PMC] [Abstract]