UDP Glucose Ceramide Glucosyltransferase (UGCG)
[Edit]GCS; GLCT-1; Glucosylceramide Synthase; N-acylsphingosine D-glucosyltransferase
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Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. They are present in essentially all animal cells and are believed to have important roles in various cellular processes. UDP-glucose ceramide glucosyltransferase (UGCG) catalyzes the first glycosylation step in GSL biosynthesis.
The product, glucosylceramide, is the core structure of more than 300 GSLs. Ichikawa et al. cloned a UGCG cDNA by expressing a human melanoma cell cDNA library in a UGCG-deficient cell line and screening for UGCG complementation. The predicted 394-amino acid UGCG protein has a potential signal-anchor sequence and a single transmembrane domain near the N terminus, and very hydrophobic regions close to the C terminus, which may interact with the membrane.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB742Mi01 | Recombinant UDP Glucose Ceramide Glucosyltransferase (UGCG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APB742Mi01 | Active UDP Glucose Ceramide Glucosyltransferase (UGCG) | Cell culture; Activity Assays. | |
| RPB742Hu01 | Recombinant UDP Glucose Ceramide Glucosyltransferase (UGCG) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB742Mi01 | Polyclonal Antibody to UDP Glucose Ceramide Glucosyltransferase (UGCG) | WB; ICC; IHC-P; IHC-F; ELISA. |
| PAB742Hu01 | Polyclonal Antibody to UDP Glucose Ceramide Glucosyltransferase (UGCG) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB742Mi | ELISA Kit for UDP Glucose Ceramide Glucosyltransferase (UGCG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB742Mi01 | Recombinant UDP Glucose Ceramide Glucosyltransferase (UGCG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APB742Mi01 | Active UDP Glucose Ceramide Glucosyltransferase (UGCG) | Cell culture; Activity Assays. | |
| Antibodies | PAB742Mi01 | Polyclonal Antibody to UDP Glucose Ceramide Glucosyltransferase (UGCG) | WB; ICC; IHC-P; IHC-F; ELISA. |
| Assay Kits | SEB742Mi | ELISA Kit for UDP Glucose Ceramide Glucosyltransferase (UGCG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB742Mi01 | Recombinant UDP Glucose Ceramide Glucosyltransferase (UGCG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APB742Mi01 | Active UDP Glucose Ceramide Glucosyltransferase (UGCG) | Cell culture; Activity Assays. | |
| Antibodies | PAB742Mi01 | Polyclonal Antibody to UDP Glucose Ceramide Glucosyltransferase (UGCG) | WB; ICC; IHC-P; IHC-F; ELISA. |
| Assay Kits | SEB742Mi | ELISA Kit for UDP Glucose Ceramide Glucosyltransferase (UGCG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis."Proc. Natl. Acad. Sci. U.S.A. 93:4638-4643(1996) [PubMed] [Europe PMC] [Abstract]
- ErratumProc. Natl. Acad. Sci. U.S.A. 93:12654-12654(1996) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]