Protein Inhibitor Of Activated STAT 1 (PIAS1)

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GBP; DDXBP1; GU/RH-II; ZMIZ3; Gu-binding protein; Zinc Finger,MIZ-Type Containing 3; DEAD/H(Asp-Glu-Ala-Asp/His)Box Binding Protein 1; RNA helicase II-binding protein

Protein Inhibitor Of Activated STAT 1 (PIAS1)

STAT proteins are latent cytoplasmic transcription factors that become activated by tyrosine phosphorylation in response to cytokine stimulation.

E3 SUMO-protein ligase PIAS1 is  a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB736Hu01 Recombinant Protein Inhibitor Of Activated STAT 1 (PIAS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB736Hu01 Polyclonal Antibody to Protein Inhibitor Of Activated STAT 1 (PIAS1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Inhibitor Of Activated STAT 1 (PIAS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Inhibitor Of Activated STAT 1 (PIAS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Inhibitor Of Activated STAT 1 (PIAS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Inhibitor Of Activated STAT 1 (PIAS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Inhibitor Of Activated STAT 1 (PIAS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Inhibitor Of Activated STAT 1 (PIAS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Inhibitor Of Activated STAT 1 (PIAS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Inhibitor Of Activated STAT 1 (PIAS1) Recombinant Protein Customized Service Offer
Antibodies PAB736Ra01 Polyclonal Antibody to Protein Inhibitor Of Activated STAT 1 (PIAS1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Inhibitor Of Activated STAT 1 (PIAS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Inhibitor Of Activated STAT 1 (PIAS1) ELISA Kit Customized Service Offer
  1. "Inhibition of Stat1-mediated gene activation by PIAS1."Proc. Natl. Acad. Sci. U.S.A. 95:10626-10631(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis."Mol. Endocrinol. 14:14-26(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site."BMC Genomics 10:518-518(2009) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and characterization of Gu/RH-II binding protein."Biochem. Biophys. Res. Commun. 234:335-340(1997) [PubMed] [Europe PMC] [Abstract]
  8. "LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1."Biochem. J. 359:485-496(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Involvement of PIAS1 in the sumoylation of tumor suppressor p53."Mol. Cell 8:713-718(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells."Oncogene 20:3880-3887(2001) [PubMed] [Europe PMC] [Abstract]
  11. "SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling."J. Biol. Chem. 277:42981-42986(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes."J. Biol. Chem. 277:50131-50136(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Transcription factor Sp3 is silenced through SUMO modification by PIAS1."EMBO J. 21:5206-5215(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity."Proc. Natl. Acad. Sci. U.S.A. 99:2872-2877(2002) [PubMed] [Europe PMC] [Abstract]
  15. "SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression."Genes Dev. 17:3048-3061(2003) [PubMed] [Europe PMC] [Abstract]
  16. "PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation."J. Biol. Chem. 278:47434-47440(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Repression of the transactivating capacity of the oncoprotein PLAG1 by SUMOylation."J. Biol. Chem. 279:36121-36131(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation."J. Biol. Chem. 281:16664-16671(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity."Cell 129:903-914(2007) [PubMed] [Europe PMC] [Abstract]
  21. "SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1."Oncogene 26:5866-5876(2007) [PubMed] [Europe PMC] [Abstract]
  22. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  23. "PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling."Genes Dev. 23:118-132(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  26. "SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function."J. Biol. Chem. 286:43793-43808(2011) [PubMed] [Europe PMC] [Abstract]
  27. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  28. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  29. "NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers."J. Biol. Chem. 279:31455-31461(2004) [PubMed] [Europe PMC] [Abstract]