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Cluster Of differentiation 299 (CD299)

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CLEC4M; CD209L; DC-SIGN2; DC-SIGNR; L-SIGN; C-Type Lectin Domain Family 4, Member M; CD209 like 1; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; Liver/lymph node-specific ICAM-3-grabbing non

Cluster Of differentiation 299 (CD299)
CCC B730
HGNC 13523
MGI 2157947
PubMed 23529928
UniProt Q9H2X3
Wiki CLEC4M

C-type lectin domain family 4 member M is a type II integral membrane protein that is 77% identical to CD209 antigen, an HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes.

The CD209L protein has an N-terminal cytoplasmic tail with a dileucine motif, which is an internalization sequence; a 22-residue transmembrane domain; an N-linked glycosylation site; a neck containing 7 repeats of a 23-residue sequence; and carbohydrate recognition domains (CRDs), which are required for calcium-dependent mannose binding.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB730Hu01 Recombinant Cluster Of differentiation 299 (CD299) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB730Hu01 Polyclonal Antibody to Cluster Of differentiation 299 (CD299) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of differentiation 299 (CD299) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of differentiation 299 (CD299) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster Of differentiation 299 (CD299) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster Of differentiation 299 (CD299) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of differentiation 299 (CD299) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of differentiation 299 (CD299) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of differentiation 299 (CD299) ELISA Kit Customized Service Offer
  1. "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank."Gene 228:161-167(1999) [PubMed] [Europe PMC] [Abstract]
  2. "DC-SIGN, a related gene, DC-SIGNR, and CD23 form a cluster on 19p13."J. Immunol. 165:2937-2942(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts."J. Biol. Chem. 276:33196-33212(2001) [PubMed] [Europe PMC] [Abstract]
  4. "A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection."J. Exp. Med. 193:671-678(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans."Proc. Natl. Acad. Sci. U.S.A. 98:2670-2675(2001) [PubMed] [Europe PMC] [Abstract]
  9. "A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands."J. Biol. Chem. 276:28939-28945(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR."J. Virol. 77:1337-1346(2003) [PubMed] [Europe PMC] [Abstract]
  11. "L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus."Proc. Natl. Acad. Sci. U.S.A. 101:14067-14072(2004) [PubMed] [Europe PMC] [Abstract]
  12. "CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus."Proc. Natl. Acad. Sci. U.S.A. 101:15748-15753(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR."Science 294:2163-2166(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR."J. Biol. Chem. 280:1327-1335(2005) [PubMed] [Europe PMC] [Abstract]
  15. "The structure of DC-SIGNR with a portion of its repeat domain lends insights to modeling of the receptor tetramer."J. Mol. Biol. 347:979-989(2005) [PubMed] [Europe PMC] [Abstract]